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- W4310571525 abstract "Mitochondrial DNA replication is an essential process in most eukaryotes. Similar to the diversity in mitochondrial genome size and organization in the different eukaryotic supergroups, there is considerable diversity in the replication process of the mitochondrial DNA. In this review, we summarize the current knowledge of mitochondrial DNA replication and the associated factors in trypanosomes with a focus on Trypanosoma brucei, and provide a new model of minicircle replication for this protozoan parasite. The model assumes the mitochondrial DNA (kinetoplast DNA, kDNA) of T. brucei to be loosely diploid in nature and the replication of the genome to occur at two replication centers at the opposing ends of the kDNA disc (also known as antipodal sites, APS). The new model is consistent with the localization of most replication factors and in contrast to the current model, it does not require the assumption of an unknown sorting and transport complex moving freshly replicated DNA to the antipodal sites. In combination with the previously proposed sexual stages of the parasite in the insect vector, the new model provides a mechanism for maintenance of the mitochondrial genetic diversity." @default.
- W4310571525 created "2022-12-12" @default.
- W4310571525 creator A5004519562 @default.
- W4310571525 creator A5050115555 @default.
- W4310571525 creator A5061301386 @default.
- W4310571525 date "2022-11-30" @default.
- W4310571525 modified "2023-10-05" @default.
- W4310571525 title "Mitochondrial genome maintenance—the kinetoplast story" @default.
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