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- W4310571714 abstract "Identifying selection on polygenic complex traits in crops and livestock is important for understanding evolution and helps prioritize important characteristics for breeding. Quantitative trait loci (QTL) that contribute to polygenic trait variation often exhibit small or infinitesimal effects. This hinders the ability to detect QTL-controlling polygenic traits because enormously high statistical power is needed for their detection. Recently, we circumvented this challenge by introducing a method to identify selection on complex traits by evaluating the relationship between genome-wide changes in allele frequency and estimates of effect size. The approach involves calculating a composite statistic across all markers that capture this relationship, followed by implementing a linkage disequilibrium-aware permutation test to evaluate if the observed pattern differs from that expected due to drift during evolution and population stratification. In this manuscript, we describe Ghat, an R package developed to implement this method to test for selection on polygenic traits. We demonstrate the package by applying it to test for polygenic selection on 15 published European wheat traits including yield, biomass, quality, morphological characteristics, and disease resistance traits. Moreover, we applied Ghat to different simulated populations with different breeding histories and genetic architectures. The results highlight the power of Ghat to identify selection on complex traits. The Ghat package is accessible on CRAN, the Comprehensive R Archival Network, and on GitHub." @default.
- W4310571714 created "2022-12-12" @default.
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- W4310571714 date "2022-12-01" @default.
- W4310571714 modified "2023-09-25" @default.
- W4310571714 title "Ghat: an R package for identifying adaptive polygenic traits" @default.
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- W4310571714 doi "https://doi.org/10.1093/g3journal/jkac319" @default.
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