FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310572059> ?p ?o ?g. }

• W4310572059 endingPage "2477" @default.
• W4310572059 startingPage "2467" @default.
• W4310572059 abstract "Acute kidney injury (AKI) is a common complication in patients, especially elderly patients, who undergo cardiac surgery with cardiopulmonary bypass. Studies have indicated a protective role of autophagy in AKI. However, the mechanisms underlying the regulatory effect of autophagy in AKI among patients undergoing cardiac surgeries are poorly understood. In this study, we aimed to test the hypothesis that exosomal microRNAs (miRNAs) regulate autophagy in tubular epithelial cells after AKI.Plasma exosomal RNA was extracted from young and elderly AKI patients undergoing cardiac surgery, and the miRNAs expression during the perioperative period were analyzed using next-generation sequencing. The screened miRNAs and their target genes were subjected to gene oncology function and Kyoto Encyclopedia of Genes and Genome enrichment analyses. Renal tubular epithelial cell line (HK-2 cells) was cultured and hypoxia/reoxygenation (H/R) model was established, which is an in vitro renal ischemia/reperfusion (I/R) model. We used Western blot analysis, cell viability assay, transfection, luciferase assay to investigate the mechanisms underlying the observed increases in the levels of renal I/R injury-mediated exosomal miRNAs and their roles in regulating HK-2 cells autophagy.miR-590-3p was highly enriched in the plasma exosomes of young AKI patients after cardiac surgery. Increased levels of miR-590-3p led to the increases in the expression of autophagy marker proteins, including Beclin-1 and microtubule associated protein 1 light chain 3 beta (LC3II), and prolonged the autophagic response in HK-2 cells after H/R treatment. These effects were achieved mainly via increases in the exosomal miR-590-3p levels, and the tumor necrosis factor receptor-associated factor 6 protein was shown to play a key role in I/R injury-mediated autophagy induction.Exosomes released from HK-2 cells after renal I/R injury regulate autophagy by transferring miR-590-3p in a paracrine manner, which suggests that increasing the miR-590-3p levels in HK-2 cell-derived exosomes may increase autophagy and protect against kidney injury after renal I/R injury." @default.
• W4310572059 created "2022-12-12" @default.
• W4310572059 creator A5001609223 @default.
• W4310572059 creator A5009862819 @default.
• W4310572059 creator A5014845250 @default.
• W4310572059 creator A5017353282 @default.
• W4310572059 creator A5020873952 @default.
• W4310572059 creator A5061119042 @default.
• W4310572059 creator A5074990695 @default.
• W4310572059 creator A5088725738 @default.
• W4310572059 date "2022-10-20" @default.
• W4310572059 modified "2023-10-03" @default.
• W4310572059 title "Exosomal transfer of microRNA-590-3p between renal tubular epithelial cells after renal ischemia-reperfusion injury regulates autophagy by targeting TRAF6" @default.
• W4310572059 cites W1655860314 @default.
• W4310572059 cites W1970680333 @default.
• W4310572059 cites W1971799714 @default.
• W4310572059 cites W2027805356 @default.
• W4310572059 cites W2052343685 @default.
• W4310572059 cites W2070254246 @default.
• W4310572059 cites W2083000528 @default.
• W4310572059 cites W2107008239 @default.
• W4310572059 cites W2109482972 @default.
• W4310572059 cites W2115093090 @default.
• W4310572059 cites W2146081758 @default.
• W4310572059 cites W2148050305 @default.
• W4310572059 cites W2151866543 @default.
• W4310572059 cites W2296538017 @default.
• W4310572059 cites W2323793261 @default.
• W4310572059 cites W2431112453 @default.
• W4310572059 cites W2593764350 @default.
• W4310572059 cites W2607394660 @default.
• W4310572059 cites W2610583794 @default.
• W4310572059 cites W2751869644 @default.
• W4310572059 cites W2777432160 @default.
• W4310572059 cites W2786514708 @default.
• W4310572059 cites W2790847363 @default.
• W4310572059 cites W2801494164 @default.
• W4310572059 cites W2890280066 @default.
• W4310572059 cites W2897917065 @default.
• W4310572059 cites W2899047088 @default.
• W4310572059 cites W2914342447 @default.
• W4310572059 cites W2949359538 @default.
• W4310572059 cites W2953559774 @default.
• W4310572059 cites W2971102494 @default.
• W4310572059 cites W2975464941 @default.
• W4310572059 cites W2995859967 @default.
• W4310572059 cites W3004063856 @default.
• W4310572059 cites W3005104290 @default.
• W4310572059 cites W3005957464 @default.
• W4310572059 cites W3033636798 @default.
• W4310572059 cites W3091605824 @default.
• W4310572059 cites W3096284313 @default.
• W4310572059 cites W3107993992 @default.
• W4310572059 cites W3128796483 @default.
• W4310572059 cites W3165259174 @default.
• W4310572059 cites W3201475081 @default.
• W4310572059 cites W3216581491 @default.
• W4310572059 cites W4200568122 @default.
• W4310572059 cites W4205781105 @default.
• W4310572059 cites W4214538340 @default.
• W4310572059 cites W594219803 @default.
• W4310572059 doi "https://doi.org/10.1097/cm9.0000000000002377" @default.
• W4310572059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36449688" @default.
• W4310572059 hasPublicationYear "2022" @default.
• W4310572059 type Work @default.
• W4310572059 citedByCount "3" @default.
• W4310572059 countsByYear W43105720592023 @default.
• W4310572059 crossrefType "journal-article" @default.
• W4310572059 hasAuthorship W4310572059A5001609223 @default.
• W4310572059 hasAuthorship W4310572059A5009862819 @default.
• W4310572059 hasAuthorship W4310572059A5014845250 @default.
• W4310572059 hasAuthorship W4310572059A5017353282 @default.
• W4310572059 hasAuthorship W4310572059A5020873952 @default.
• W4310572059 hasAuthorship W4310572059A5061119042 @default.
• W4310572059 hasAuthorship W4310572059A5074990695 @default.
• W4310572059 hasAuthorship W4310572059A5088725738 @default.
• W4310572059 hasBestOaLocation W43105720591 @default.
• W4310572059 hasConcept C104317684 @default.
• W4310572059 hasConcept C126322002 @default.
• W4310572059 hasConcept C127561419 @default.
• W4310572059 hasConcept C145059251 @default.
• W4310572059 hasConcept C190283241 @default.
• W4310572059 hasConcept C203522944 @default.
• W4310572059 hasConcept C20518536 @default.
• W4310572059 hasConcept C22615655 @default.
• W4310572059 hasConcept C2776415932 @default.
• W4310572059 hasConcept C2780114680 @default.
• W4310572059 hasConcept C2780472472 @default.
• W4310572059 hasConcept C2780721119 @default.
• W4310572059 hasConcept C2781261824 @default.
• W4310572059 hasConcept C502942594 @default.
• W4310572059 hasConcept C54009773 @default.
• W4310572059 hasConcept C541997718 @default.
• W4310572059 hasConcept C54355233 @default.
• W4310572059 hasConcept C55493867 @default.
• W4310572059 hasConcept C71924100 @default.
• W4310572059 hasConcept C81885089 @default.
• W4310572059 hasConcept C86803240 @default.

• next