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- W4310572892 abstract "A lipid droplet (LD) is an organelle that consists of a phospholipid monolayer and a neutral lipid core, with proteins embedded in or attached to its surface. Until recently, cancers had long been regarded as genetic disorders with the abnormal activation of oncogenes and inactivation of tumor suppressor genes before their quality of a metabolic disorder began to be recognized. The last decade has witnessed the recognition of several metabolic characteristics of cancer cells, among which one is the accumulation of lipid droplets; therefore, attention has been given to exploring the role of LDs in carcinomas. In addition, there has been a remarkable expansion in understanding the complexity of LD's function in cellular homeostasis, including but not limited to energy supply, endoplasmic reticulum (ER) stress and oxidative stress management, or lipotoxicity alleviation. Thus, lipid droplet-associated proteins, which to a great extent determine the dynamics of a lipid droplet, have attracted the interest of numerous cancer researchers and their potential as cancer diagnostic biomarkers and therapeutic targets has been affirmed by emerging evidence. In this review, we systematically summarize the critical role of LDs in cancer and then focus on four categories of lipid droplet-associated proteins having the most direct influence on LD biosynthesis (diacylglycerol acyltransferase 1 (DGAT1) and diacylglycerol acyltransferase 2 (DGAT2)), degradation (adipose triglyceride lipase (ATGL)), and two renowned protein families on the LD surface (perilipins and cell death-inducing DNA fragmentation factor alpha-like effectors (CIDEs)). In this way, we aim to highlight their important role in tumor progression and their potential in clinical applications." @default.
- W4310572892 created "2022-12-12" @default.
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- W4310572892 date "2022-01-01" @default.
- W4310572892 modified "2023-10-17" @default.
- W4310572892 title "Adding fuel to the fire: The lipid droplet and its associated proteins in cancer progression" @default.
- W4310572892 cites W1005186095 @default.
- W4310572892 cites W1706150252 @default.
- W4310572892 cites W1970375047 @default.
- W4310572892 cites W1975229775 @default.
- W4310572892 cites W1978093763 @default.
- W4310572892 cites W1980568044 @default.
- W4310572892 cites W1983754278 @default.
- W4310572892 cites W1986170164 @default.
- W4310572892 cites W1997238838 @default.
- W4310572892 cites W2000002411 @default.
- W4310572892 cites W2001944628 @default.
- W4310572892 cites W2002232196 @default.
- W4310572892 cites W2004718580 @default.
- W4310572892 cites W2007505836 @default.
- W4310572892 cites W2010819467 @default.
- W4310572892 cites W2012037560 @default.
- W4310572892 cites W2019845776 @default.
- W4310572892 cites W2020389453 @default.
- W4310572892 cites W2021882008 @default.
- W4310572892 cites W2022271256 @default.
- W4310572892 cites W2023947368 @default.
- W4310572892 cites W2024145410 @default.
- W4310572892 cites W2026497980 @default.
- W4310572892 cites W2032613519 @default.
- W4310572892 cites W2032860037 @default.
- W4310572892 cites W2034889452 @default.
- W4310572892 cites W2035310767 @default.
- W4310572892 cites W2036555284 @default.
- W4310572892 cites W2039378889 @default.
- W4310572892 cites W2044052768 @default.
- W4310572892 cites W2046961412 @default.
- W4310572892 cites W2055971882 @default.
- W4310572892 cites W2056633943 @default.
- W4310572892 cites W2057258619 @default.
- W4310572892 cites W2063774526 @default.
- W4310572892 cites W2065468070 @default.
- W4310572892 cites W2068919366 @default.
- W4310572892 cites W2073162567 @default.
- W4310572892 cites W2080828572 @default.
- W4310572892 cites W2081200438 @default.
- W4310572892 cites W2081962941 @default.
- W4310572892 cites W2090946848 @default.
- W4310572892 cites W2091718432 @default.
- W4310572892 cites W2094093571 @default.
- W4310572892 cites W2094744133 @default.
- W4310572892 cites W2097259163 @default.
- W4310572892 cites W2097521595 @default.
- W4310572892 cites W2099429838 @default.
- W4310572892 cites W2110839026 @default.
- W4310572892 cites W2115152218 @default.
- W4310572892 cites W2121233961 @default.
- W4310572892 cites W2123844682 @default.
- W4310572892 cites W2124349052 @default.
- W4310572892 cites W2127938073 @default.
- W4310572892 cites W2130616164 @default.
- W4310572892 cites W2131256997 @default.
- W4310572892 cites W2131290128 @default.
- W4310572892 cites W2132349645 @default.
- W4310572892 cites W2135546443 @default.
- W4310572892 cites W2136194082 @default.
- W4310572892 cites W2136558879 @default.
- W4310572892 cites W2142178488 @default.
- W4310572892 cites W2147166694 @default.
- W4310572892 cites W2147821881 @default.
- W4310572892 cites W2149639441 @default.
- W4310572892 cites W2150101070 @default.
- W4310572892 cites W2153178365 @default.
- W4310572892 cites W2155170725 @default.
- W4310572892 cites W2161164517 @default.
- W4310572892 cites W2162695817 @default.
- W4310572892 cites W2163861471 @default.
- W4310572892 cites W2164346983 @default.
- W4310572892 cites W2168979361 @default.
- W4310572892 cites W2171352537 @default.
- W4310572892 cites W2177040066 @default.
- W4310572892 cites W2220777476 @default.
- W4310572892 cites W2234115940 @default.
- W4310572892 cites W2267873322 @default.
- W4310572892 cites W2291752147 @default.
- W4310572892 cites W2293141975 @default.