Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310584073> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4310584073 abstract "The aim of this work is to design and employ a large-aperture focused transducer with a holographic lens to selectively sonicate small deep-brain structures in non-human primates, such as the left post-commissural putamen, correcting skull aberrations and obtaining a good quality focal spot. Acoustic hologram was designed with time-reversal methods and numerical simulations with a k-space pseudospectral method. Its performance was experimentally evaluated with an ex-vivo macaque skull in water with direct measurements. To avoid undesired artefacts and retrieve the whole acoustic field, the focal region was also reconstructed by holographic projections of measurements taken at a 2D plane. Simulation, direct measurements and holographic projection results are in good agreement, with the focus lying into the therapeutical target location. We experimentally obtained that 38 % of the target volume is sonicated with a pressure higher than half the focus maximum, getting more than 0.5 MPa rarefaction pressure. We present that holographic lenses coupled to large-aperture focused transducers allow for precise targeting of small deep brain structures at sufficient amplitudes to generate cavitation. This technology is presented as a low-cost system for preclinical localized drug delivery." @default.
- W4310584073 created "2022-12-12" @default.
- W4310584073 creator A5009448778 @default.
- W4310584073 creator A5023850435 @default.
- W4310584073 creator A5033737826 @default.
- W4310584073 creator A5050038534 @default.
- W4310584073 creator A5054555300 @default.
- W4310584073 creator A5055649182 @default.
- W4310584073 date "2022-10-10" @default.
- W4310584073 modified "2023-09-27" @default.
- W4310584073 title "Design and Holographic Field Reconstruction of Ultrasonic Lenses for Drug Delivery in non-Human Primates" @default.
- W4310584073 cites W1970683344 @default.
- W4310584073 cites W1998953558 @default.
- W4310584073 cites W2001881071 @default.
- W4310584073 cites W2114596635 @default.
- W4310584073 cites W2130244962 @default.
- W4310584073 cites W2162473564 @default.
- W4310584073 cites W2522831503 @default.
- W4310584073 cites W2772817913 @default.
- W4310584073 cites W2791250514 @default.
- W4310584073 cites W2923307410 @default.
- W4310584073 cites W2974176124 @default.
- W4310584073 cites W2976433890 @default.
- W4310584073 cites W2981777948 @default.
- W4310584073 cites W3104646045 @default.
- W4310584073 cites W3107465768 @default.
- W4310584073 cites W3159357008 @default.
- W4310584073 cites W4214652234 @default.
- W4310584073 cites W4225305638 @default.
- W4310584073 cites W4283391600 @default.
- W4310584073 doi "https://doi.org/10.1109/ius54386.2022.9957745" @default.
- W4310584073 hasPublicationYear "2022" @default.
- W4310584073 type Work @default.
- W4310584073 citedByCount "0" @default.
- W4310584073 crossrefType "proceedings-article" @default.
- W4310584073 hasAuthorship W4310584073A5009448778 @default.
- W4310584073 hasAuthorship W4310584073A5023850435 @default.
- W4310584073 hasAuthorship W4310584073A5033737826 @default.
- W4310584073 hasAuthorship W4310584073A5050038534 @default.
- W4310584073 hasAuthorship W4310584073A5054555300 @default.
- W4310584073 hasAuthorship W4310584073A5055649182 @default.
- W4310584073 hasConcept C120665830 @default.
- W4310584073 hasConcept C121332964 @default.
- W4310584073 hasConcept C15336307 @default.
- W4310584073 hasConcept C187590223 @default.
- W4310584073 hasConcept C192209626 @default.
- W4310584073 hasConcept C192562407 @default.
- W4310584073 hasConcept C24890656 @default.
- W4310584073 hasConcept C41008148 @default.
- W4310584073 hasConcept C56318395 @default.
- W4310584073 hasConcept C78336883 @default.
- W4310584073 hasConceptScore W4310584073C120665830 @default.
- W4310584073 hasConceptScore W4310584073C121332964 @default.
- W4310584073 hasConceptScore W4310584073C15336307 @default.
- W4310584073 hasConceptScore W4310584073C187590223 @default.
- W4310584073 hasConceptScore W4310584073C192209626 @default.
- W4310584073 hasConceptScore W4310584073C192562407 @default.
- W4310584073 hasConceptScore W4310584073C24890656 @default.
- W4310584073 hasConceptScore W4310584073C41008148 @default.
- W4310584073 hasConceptScore W4310584073C56318395 @default.
- W4310584073 hasConceptScore W4310584073C78336883 @default.
- W4310584073 hasLocation W43105840731 @default.
- W4310584073 hasOpenAccess W4310584073 @default.
- W4310584073 hasPrimaryLocation W43105840731 @default.
- W4310584073 hasRelatedWork W1965627369 @default.
- W4310584073 hasRelatedWork W1977332644 @default.
- W4310584073 hasRelatedWork W2045345838 @default.
- W4310584073 hasRelatedWork W2081009350 @default.
- W4310584073 hasRelatedWork W2090693644 @default.
- W4310584073 hasRelatedWork W2105182073 @default.
- W4310584073 hasRelatedWork W2128950493 @default.
- W4310584073 hasRelatedWork W2548234628 @default.
- W4310584073 hasRelatedWork W2944438779 @default.
- W4310584073 hasRelatedWork W2493204139 @default.
- W4310584073 isParatext "false" @default.
- W4310584073 isRetracted "false" @default.
- W4310584073 workType "article" @default.