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- W4310584543 abstract "Functional ultrasound imaging (fUSI) is a promising new modality for neuroimaging that measures the power Doppler signal as a proxy for neural activation. However, clinical translation of noninvasive, transcranial fUSI (tfUSI) is hindered by the low signal-to-noise ratio (SNR) from the skull which greatly limits blood flow sensitivity. To overcome this issue, we demonstrate a coded excitation approach to increase SNR in transcranial power Doppler imaging and thereby increase blood flow sensitivity. In three healthy adult subjects we showed an average SNR gain of 17.77 <tex xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>$pm 1.05 mathbf{dB}$</tex> , contrast-to-noise ratio gain of 4.97 <tex xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>$pm 4.18 mathbf{dB}$</tex> , and contrast ratio gain of <tex xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>$22.53 pm 11.34 text{dB}$</tex> using a 65 bit code. These promising results indicate that tfUSI may be feasible using our coded excitation approach." @default.
- W4310584543 created "2022-12-12" @default.
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- W4310584543 date "2022-10-10" @default.
- W4310584543 modified "2023-09-27" @default.
- W4310584543 title "Coded Excitation for Increased Sensitivity in Transcranial Power Doppler Imaging" @default.
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- W4310584543 doi "https://doi.org/10.1109/ius54386.2022.9958842" @default.
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