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- W4310584582 abstract "Spinal cord is crucial to nerve conduction pathway. Traumatic spinal cord injury often results in a lifelong sensation loss or even paralysis. A major mechanism is vasculature disruption after primary insult and further abnormal responses of the intact vessels in neighboring tissue during secondary injury. Microvasculature and related blood supply play important roles in spinal cord injury (SCI) evaluation. Digital subtraction angiography (DSA) and magnetic resonance angiography (MRA) are still the standard method in clinics. Recently developed ultrasound localization microscopy (ULM) enables to map the microvasculature of small animal in deep tissue with a resolution of tens of microns. With the advantage of non-radiation, portability and super-resolution, it has become an attractive alternative for angiography and could potentially meet the needs of comprehensive intraoperative examination and prognosis tracking. In this study, ULM was performed on a standardized rat animal model of spinal cord compression for in vivo SCI imaging. Basso, Beattie, Bresnahan (BBB) locomotor rating scale and hematoxylin-eosin (H&E) staining were utilized for model validation. Microvasculature changes concerning morphology, density and velocity are observed in ULM results of pre-injury and post-injury states." @default.
- W4310584582 created "2022-12-12" @default.
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- W4310584582 date "2022-10-10" @default.
- W4310584582 modified "2023-09-27" @default.
- W4310584582 title "Ultrasound Localization Microscopy for Compression-Induced Spinal Cord Injury Evaluation" @default.
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- W4310584582 doi "https://doi.org/10.1109/ius54386.2022.9957854" @default.
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