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- W4310589097 abstract "Hyperprolactinemia has been proven to induce hypogonadism and metabolic derangements in both genders, while the consequences of prolactin (PRL) deficiency have been poorly investigated.To systematically review and analyze data from clinical studies focusing on the metabolic consequences of abnormally high prolactin levels (HPRL) and low prolactin levels (LPRL). In addition, data from preclinical studies about underlying pathophysiological mechanisms were summarized and discussed.PRL contributes to providing the correct amount of energy to support the mother and the fetus/offspring during pregnancy and lactation, but it also has a homeostatic role. Pathological PRL elevation beyond these physiological conditions, but also its reduction, impairs metabolism and body composition in both genders, increasing the risk of diabetes and cardiovascular events. Hence, hypoprolactinemia should be avoided as much as possible during treatment with dopamine agonists for prolactinomas. Patients with hypoprolactinemia, because of endogenous or iatrogenic conditions, deserve, as those with hyperprolactinemia, careful metabolic assessment." @default.
- W4310589097 created "2022-12-12" @default.
- W4310589097 creator A5015998600 @default.
- W4310589097 creator A5021208002 @default.
- W4310589097 creator A5034592726 @default.
- W4310589097 creator A5049129057 @default.
- W4310589097 creator A5049759930 @default.
- W4310589097 creator A5056340385 @default.
- W4310589097 creator A5059786789 @default.
- W4310589097 creator A5091839639 @default.
- W4310589097 date "2022-11-02" @default.
- W4310589097 modified "2023-09-29" @default.
- W4310589097 title "The metabolic role of prolactin: systematic review, meta-analysis and preclinical considerations" @default.
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