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• W4310594219 endingPage "5451" @default.
• W4310594219 startingPage "5437" @default.
• W4310594219 abstract "Abstract Objective Breast cancer (BC) is one of the most commonly diagnosed solid malignancies in women worldwide. Purpose Finding new non-invasive circulating diagnostic biomarkers will facilitate the early prediction of BC and provide valuable insight into disease progression and response to therapy using a safe and more accessible approach available every inspection time. Therefore, our present study aimed to investigate expression patterns of potentially circulating biomarkers that can differentiate well between benign, malignant, and healthy subjects. Methods To achieve our target, quantitative analyses were performed for some circulating biomarkers which have a role in the proliferation and tumor growth, as well as, glutamic acid, and human epidermal growth receptor 2 (HER2) in blood samples of BC patients in comparison to healthy controls using qRT-PCR, liquid chromatography/mass spectrometry (LC/MS/MS), and ELISA. Results Our findings showed that the two miRNAs (miRNA-145, miRNA-382) were expressed at lower levels in BC sera than healthy control group, while miRNA-21 was expressed at higher levels in BC patients than control subjects. Area under ROC curves of BC samples revealed that AUC of miRNA-145, miRNA-382, miRNA-21, and glutamic acid was evaluated to equal 0.99, 1.00, 1.00 and 1.00, respectively. Besides, there was a significantly positive correlation between miRNA-145 and miRNA-382 ( r = 0.737), and a highly significant positive correlation between miRNA-21 and glutamic acid ( r = 0.385). Conclusion Based on our results, we conclude that the detection of serum miRNA-145, -382 and -21 as a panel along with glutamic acid, and circulating HER2 concentrations could be useful as a non-invasive diagnostic profiling for early prediction of breast cancer in Egyptian patients. It can provide an insight into disease progression, discriminate between malignancy and healthy control, and overcome the use limitations (low sensitivity and specificity, repeated risky exposure, and high cost) of other detecting tools, including mammography, magnetic resonance imaging, and ultrasound." @default.
• W4310594219 created "2022-12-12" @default.
• W4310594219 creator A5022391701 @default.
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• W4310594219 date "2022-12-02" @default.
• W4310594219 modified "2023-10-02" @default.
• W4310594219 title "The diagnostic significance of circulating miRNAs and metabolite profiling in early prediction of breast cancer in Egyptian women" @default.
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• W4310594219 doi "https://doi.org/10.1007/s00432-022-04492-2" @default.
• W4310594219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36459290" @default.
• W4310594219 hasPublicationYear "2022" @default.
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