Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310595611> ?p ?o ?g. }
- W4310595611 abstract "Viruses have evolved diverse mechanisms to antagonize host immunity such as direct inhibition and relocalization of cellular APOBEC3B (A3B) by the ribonucleotide reductase (RNR) of Epstein-Barr virus. Here, we investigate the mechanistic conservation and evolutionary origin of this innate immune counteraction strategy. First, we find that human gamma-herpesvirus RNRs engage A3B via largely distinct surfaces. Second, we show that RNR-mediated enzymatic inhibition and relocalization of A3B depend upon binding to different regions of the catalytic domain. Third, we show that the capability of viral RNRs to antagonize A3B is conserved among gamma-herpesviruses that infect humans and Old World monkeys that encode this enzyme but absent in homologous viruses that infect New World monkeys that naturally lack the A3B gene. Finally, we reconstruct the ancestral primate A3B protein and demonstrate that it is active and similarly engaged by the RNRs from viruses that infect humans and Old World monkeys but not by the RNRs from viruses that infect New World monkeys. These results combine to indicate that the birth of A3B at a critical branchpoint in primate evolution may have been a driving force in selecting for an ancestral gamma-herpesvirus with an expanded RNR functionality through counteraction of this antiviral enzyme." @default.
- W4310595611 created "2022-12-12" @default.
- W4310595611 creator A5019225633 @default.
- W4310595611 creator A5037696772 @default.
- W4310595611 creator A5044766207 @default.
- W4310595611 creator A5062306958 @default.
- W4310595611 creator A5067224287 @default.
- W4310595611 creator A5071846430 @default.
- W4310595611 creator A5080368267 @default.
- W4310595611 date "2022-12-02" @default.
- W4310595611 modified "2023-10-14" @default.
- W4310595611 title "Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases" @default.
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