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• W4310595921 startingPage "867" @default.
• W4310595921 abstract "The major histocompatibility complex (MHC) genes are central to the adaptive immune response in vertebrates. Selection generally maintains high MHC variation because the spectrum of recognized pathogens depends on MHC polymorphism. Novel alleles favoured by selection originate by interallelic recombination or de novo mutations but may also be acquired by introgression from related species. However, the extent and prevalence of MHC introgression remain an open question. In this study, we tested for MHC introgression in six hybrid zones formed by six Triturus newt species. We sequenced and genotyped the polymorphic second exons of the MHC class I and II genes and compared their interspecific similarity at various distances from the centre of the hybrid zone. We found evidence for introgression of both MHC classes in the majority of examined hybrid zones, with support for a more substantial class I introgression. Furthermore, the overall MHC allele sharing outside of hybrid zones was elevated between pairs of Triturus species with abutting ranges, regardless of the phylogenetic distance between them. No effect of past hybrid zone movement on MHC allele sharing was found. Finally, using previously published genome-wide data, we demonstrated that MHC introgression was more extensive than genome-wide introgression, supporting its adaptive potential. Our study thus provides evidence for the prevalence of MHC introgression across multiple Triturus hybrid zones, indicating that MHC introgression between divergent hybridizing species may be widespread and adaptive." @default.
• W4310595921 created "2022-12-12" @default.
• W4310595921 creator A5024869766 @default.
• W4310595921 creator A5044656396 @default.
• W4310595921 creator A5047658599 @default.
• W4310595921 creator A5054877198 @default.
• W4310595921 creator A5066676283 @default.
• W4310595921 creator A5075778906 @default.
• W4310595921 date "2022-12-16" @default.
• W4310595921 modified "2023-09-30" @default.
• W4310595921 title "Interspecific introgression of <scp>MHC</scp> genes in <i>Triturus</i> newts: Evidence from multiple contact zones" @default.
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