Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310596323> ?p ?o ?g. }
- W4310596323 abstract "Genome-scale metabolic reconstruction tools have been developed in the last decades. They have helped to reconstruct eukaryotic and prokaryotic metabolic models, which have contributed to fields, e.g., genetic engineering, drug discovery, prediction of phenotypes, and other model-driven discoveries. However, the use of these programs requires a high level of bioinformatic skills. Moreover, the functionalities required to build models are scattered throughout multiple tools, requiring knowledge and experience for utilizing several tools.Here we present ChiMera, which combines tools used for model reconstruction, prediction, and visualization. ChiMera uses CarveMe in the reconstruction module, generating a gap-filled draft reconstruction able to produce growth predictions using flux balance analysis for gram-positive and gram-negative bacteria. ChiMera also contains two modules for metabolic network visualization. The first module generates maps for the most important pathways, e.g., glycolysis, nucleotides and amino acids biosynthesis, fatty acid oxidation and biosynthesis and core-metabolism. The second module produces a genome-wide metabolic map, which can be used to retrieve KEGG pathway information for each compound in the model. A module to investigate gene essentiality and knockout is also present.Overall, ChiMera uses automation algorithms to combine a variety of tools to automatically perform model creation, gap-filling, flux balance analysis (FBA), and metabolic network visualization. ChiMera models readily provide metabolic insights that can aid genetic engineering projects, prediction of phenotypes, and model-driven discoveries." @default.
- W4310596323 created "2022-12-12" @default.
- W4310596323 creator A5051413186 @default.
- W4310596323 creator A5063348766 @default.
- W4310596323 creator A5072461088 @default.
- W4310596323 creator A5075816254 @default.
- W4310596323 creator A5088247271 @default.
- W4310596323 date "2022-11-30" @default.
- W4310596323 modified "2023-10-15" @default.
- W4310596323 title "ChiMera: an easy to use pipeline for bacterial genome based metabolic network reconstruction, evaluation and visualization" @default.
- W4310596323 cites W1665355332 @default.
- W4310596323 cites W1999938932 @default.
- W4310596323 cites W2044935306 @default.
- W4310596323 cites W2048465561 @default.
- W4310596323 cites W2079531107 @default.
- W4310596323 cites W2085630244 @default.
- W4310596323 cites W2085966233 @default.
- W4310596323 cites W2085993965 @default.
- W4310596323 cites W2100084634 @default.
- W4310596323 cites W2124737787 @default.
- W4310596323 cites W2157253968 @default.
- W4310596323 cites W2159675211 @default.
- W4310596323 cites W2163240970 @default.
- W4310596323 cites W2164997719 @default.
- W4310596323 cites W2168465568 @default.
- W4310596323 cites W2272415328 @default.
- W4310596323 cites W2522753993 @default.
- W4310596323 cites W2764202526 @default.
- W4310596323 cites W2804977648 @default.
- W4310596323 cites W2949418748 @default.
- W4310596323 cites W2966440819 @default.
- W4310596323 cites W2982500515 @default.
- W4310596323 cites W3010629926 @default.
- W4310596323 cites W3129451883 @default.
- W4310596323 cites W4200380646 @default.
- W4310596323 cites W4282838866 @default.
- W4310596323 doi "https://doi.org/10.1186/s12859-022-05056-4" @default.
- W4310596323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36451100" @default.
- W4310596323 hasPublicationYear "2022" @default.
- W4310596323 type Work @default.
- W4310596323 citedByCount "4" @default.
- W4310596323 countsByYear W43105963232022 @default.
- W4310596323 countsByYear W43105963232023 @default.
- W4310596323 crossrefType "journal-article" @default.
- W4310596323 hasAuthorship W4310596323A5051413186 @default.
- W4310596323 hasAuthorship W4310596323A5063348766 @default.
- W4310596323 hasAuthorship W4310596323A5072461088 @default.
- W4310596323 hasAuthorship W4310596323A5075816254 @default.
- W4310596323 hasAuthorship W4310596323A5088247271 @default.
- W4310596323 hasBestOaLocation W43105963231 @default.
- W4310596323 hasConcept C101810790 @default.
- W4310596323 hasConcept C104317684 @default.
- W4310596323 hasConcept C115901376 @default.
- W4310596323 hasConcept C124101348 @default.
- W4310596323 hasConcept C127413603 @default.
- W4310596323 hasConcept C134018914 @default.
- W4310596323 hasConcept C141231307 @default.
- W4310596323 hasConcept C152662350 @default.
- W4310596323 hasConcept C160941953 @default.
- W4310596323 hasConcept C167091322 @default.
- W4310596323 hasConcept C191908910 @default.
- W4310596323 hasConcept C36464697 @default.
- W4310596323 hasConcept C41008148 @default.
- W4310596323 hasConcept C54355233 @default.
- W4310596323 hasConcept C60644358 @default.
- W4310596323 hasConcept C62231903 @default.
- W4310596323 hasConcept C6350086 @default.
- W4310596323 hasConcept C70721500 @default.
- W4310596323 hasConcept C78519656 @default.
- W4310596323 hasConcept C86803240 @default.
- W4310596323 hasConceptScore W4310596323C101810790 @default.
- W4310596323 hasConceptScore W4310596323C104317684 @default.
- W4310596323 hasConceptScore W4310596323C115901376 @default.
- W4310596323 hasConceptScore W4310596323C124101348 @default.
- W4310596323 hasConceptScore W4310596323C127413603 @default.
- W4310596323 hasConceptScore W4310596323C134018914 @default.
- W4310596323 hasConceptScore W4310596323C141231307 @default.
- W4310596323 hasConceptScore W4310596323C152662350 @default.
- W4310596323 hasConceptScore W4310596323C160941953 @default.
- W4310596323 hasConceptScore W4310596323C167091322 @default.
- W4310596323 hasConceptScore W4310596323C191908910 @default.
- W4310596323 hasConceptScore W4310596323C36464697 @default.
- W4310596323 hasConceptScore W4310596323C41008148 @default.
- W4310596323 hasConceptScore W4310596323C54355233 @default.
- W4310596323 hasConceptScore W4310596323C60644358 @default.
- W4310596323 hasConceptScore W4310596323C62231903 @default.
- W4310596323 hasConceptScore W4310596323C6350086 @default.
- W4310596323 hasConceptScore W4310596323C70721500 @default.
- W4310596323 hasConceptScore W4310596323C78519656 @default.
- W4310596323 hasConceptScore W4310596323C86803240 @default.
- W4310596323 hasFunder F4320320997 @default.
- W4310596323 hasFunder F4320321091 @default.
- W4310596323 hasIssue "1" @default.
- W4310596323 hasLocation W43105963231 @default.
- W4310596323 hasLocation W43105963232 @default.
- W4310596323 hasLocation W43105963233 @default.
- W4310596323 hasLocation W43105963234 @default.
- W4310596323 hasLocation W43105963235 @default.
- W4310596323 hasLocation W43105963236 @default.
- W4310596323 hasLocation W43105963237 @default.