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- W4310596893 abstract "Long noncoding RNAs (lncRNAs) are a diverse class of RNAs that are critical for gene regulation, DNA repair, and splicing, and have been implicated in development, stress response, and cancer. However, the functions of many lncRNAs remain unknown. In Drosophila melanogaster, U snoRNA host gene 4 (Uhg4) encodes an antisense long noncoding RNA that is host to seven small nucleolar RNAs (snoRNAs). Uhg4 is expressed ubiquitously during development and in all adult tissues, with maximal expression in ovaries; however, it has no annotated function(s).We used CRISPR-Cas9 germline gene editing to generate multiple deletions spanning the promoter region and first exon of Uhg4. Females showed arrested egg development and both males and females were sterile. In addition, Uhg4 deletion mutants showed delayed development and decreased viability, and changes in sleep and responses to stress. Whole-genome RNA sequencing of Uhg4 deletion flies and their controls identified co-regulated genes and genetic interaction networks associated with Uhg4. Gene ontology analyses highlighted a broad spectrum of biological processes, including regulation of transcription and translation, morphogenesis, and stress response.Uhg4 is a lncRNA essential for reproduction with pleiotropic effects on multiple fitness traits." @default.
- W4310596893 created "2022-12-12" @default.
- W4310596893 creator A5004400034 @default.
- W4310596893 creator A5028037557 @default.
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- W4310596893 creator A5069386405 @default.
- W4310596893 creator A5079941362 @default.
- W4310596893 creator A5089353484 @default.
- W4310596893 creator A5089703622 @default.
- W4310596893 date "2022-11-30" @default.
- W4310596893 modified "2023-10-10" @default.
- W4310596893 title "Pleiotropic fitness effects of the lncRNA Uhg4 in Drosophila melanogaster" @default.
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