Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310598475> ?p ?o ?g. }
- W4310598475 endingPage "111721" @default.
- W4310598475 startingPage "111721" @default.
- W4310598475 abstract "Influenza infection is substantially worsened by the onset of secondary pneumonia caused by bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). The bidirectional interaction between the influenza-injured lung microenvironment and MRSA is poorly understood. By conditioning MRSA ex vivo in bronchoalveolar lavage fluid collected from mice at various time points of influenza infection, we found that the influenza-injured lung microenvironment dynamically induces MRSA to increase cytotoxin expression while decreasing metabolic pathways. LukAB, a SaeRS two-component system-dependent cytotoxin, is particularly important to the severity of post-influenza MRSA pneumonia. LukAB's activity is likely shaped by the post-influenza lung microenvironment, as LukAB binds to (and is activated by) heparan sulfate (HS) oligosaccharide sequences shed from the epithelial glycocalyx after influenza. Our findings indicate that post-influenza MRSA pneumonia is shaped by bidirectional host-pathogen interactions: host injury triggers changes in bacterial expression of toxins, the activity of which may be shaped by host-derived HS fragments." @default.
- W4310598475 created "2022-12-12" @default.
- W4310598475 creator A5018492850 @default.
- W4310598475 creator A5019820210 @default.
- W4310598475 creator A5034057755 @default.
- W4310598475 creator A5040381195 @default.
- W4310598475 creator A5042721262 @default.
- W4310598475 creator A5044606499 @default.
- W4310598475 creator A5044790034 @default.
- W4310598475 creator A5046166989 @default.
- W4310598475 creator A5053824001 @default.
- W4310598475 creator A5060165452 @default.
- W4310598475 creator A5069724772 @default.
- W4310598475 creator A5071111671 @default.
- W4310598475 creator A5076307322 @default.
- W4310598475 creator A5078323762 @default.
- W4310598475 creator A5078445016 @default.
- W4310598475 creator A5078787349 @default.
- W4310598475 creator A5089324530 @default.
- W4310598475 creator A5089438881 @default.
- W4310598475 date "2022-11-01" @default.
- W4310598475 modified "2023-09-28" @default.
- W4310598475 title "The influenza-injured lung microenvironment promotes MRSA virulence, contributing to severe secondary bacterial pneumonia" @default.
- W4310598475 cites W1214154301 @default.
- W4310598475 cites W1487835629 @default.
- W4310598475 cites W1502615329 @default.
- W4310598475 cites W1503194715 @default.
- W4310598475 cites W1586842765 @default.
- W4310598475 cites W1828765542 @default.
- W4310598475 cites W1898442347 @default.
- W4310598475 cites W1963912540 @default.
- W4310598475 cites W1967437340 @default.
- W4310598475 cites W1995615618 @default.
- W4310598475 cites W1996486159 @default.
- W4310598475 cites W2010457001 @default.
- W4310598475 cites W2036177806 @default.
- W4310598475 cites W2044730705 @default.
- W4310598475 cites W2046700055 @default.
- W4310598475 cites W2050161704 @default.
- W4310598475 cites W2065045107 @default.
- W4310598475 cites W2065921144 @default.
- W4310598475 cites W2067215762 @default.
- W4310598475 cites W2084046310 @default.
- W4310598475 cites W2090536138 @default.
- W4310598475 cites W2101078720 @default.
- W4310598475 cites W2101940366 @default.
- W4310598475 cites W2103443709 @default.
- W4310598475 cites W2105431972 @default.
- W4310598475 cites W2107060225 @default.
- W4310598475 cites W2110420249 @default.
- W4310598475 cites W2110763275 @default.
- W4310598475 cites W2115127793 @default.
- W4310598475 cites W2115442028 @default.
- W4310598475 cites W2116607488 @default.
- W4310598475 cites W2121452572 @default.
- W4310598475 cites W2125258157 @default.
- W4310598475 cites W2126812384 @default.
- W4310598475 cites W2132643319 @default.
- W4310598475 cites W2139954389 @default.
- W4310598475 cites W2141224543 @default.
- W4310598475 cites W2143655767 @default.
- W4310598475 cites W2145702653 @default.
- W4310598475 cites W2163305262 @default.
- W4310598475 cites W2163500926 @default.
- W4310598475 cites W2171629802 @default.
- W4310598475 cites W2179438025 @default.
- W4310598475 cites W2275434793 @default.
- W4310598475 cites W2298105916 @default.
- W4310598475 cites W2325157083 @default.
- W4310598475 cites W2528158691 @default.
- W4310598475 cites W2528986999 @default.
- W4310598475 cites W2564915973 @default.
- W4310598475 cites W2573336339 @default.
- W4310598475 cites W2578231256 @default.
- W4310598475 cites W2583544517 @default.
- W4310598475 cites W2607187374 @default.
- W4310598475 cites W2745764414 @default.
- W4310598475 cites W2773676586 @default.
- W4310598475 cites W2783764158 @default.
- W4310598475 cites W2794481632 @default.
- W4310598475 cites W2800337450 @default.
- W4310598475 cites W2801364533 @default.
- W4310598475 cites W2805311695 @default.
- W4310598475 cites W2810845726 @default.
- W4310598475 cites W2889723928 @default.
- W4310598475 cites W2900938574 @default.
- W4310598475 cites W2907641591 @default.
- W4310598475 cites W2914375952 @default.
- W4310598475 cites W2921665268 @default.
- W4310598475 cites W2926414609 @default.
- W4310598475 cites W2946936766 @default.
- W4310598475 cites W2947210068 @default.
- W4310598475 cites W2960411720 @default.
- W4310598475 cites W2973215277 @default.
- W4310598475 cites W2980475721 @default.
- W4310598475 cites W2990396305 @default.
- W4310598475 cites W2996595768 @default.
- W4310598475 cites W3011041389 @default.