FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310600302> ?p ?o ?g. }

• W4310600302 endingPage "696" @default.
• W4310600302 startingPage "688" @default.
• W4310600302 abstract "Abstract Background and hypothesis Phosphodiesterase 10A (PDE10A) is a highly expressed enzyme in the basal ganglia, where cortical glutamatergic and midbrain dopaminergic inputs are integrated. Therapeutic PDE10A inhibition effects on schizophrenia have been reported previously, but the status of this molecule in the living patients with schizophrenia remains elusive. Therefore, this study aimed to investigate the central PDE10A status in patients with schizophrenia and examine its relationship with psychopathology, cognition, and corticostriatal glutamate levels. Study design This study included 27 patients with schizophrenia, with 5 antipsychotic-free cases, and 27 healthy controls. Positron emission tomography with [18F]MNI-659, a specific PDE10A radioligand, was employed to quantify PDE10A availability by measuring non-displaceable binding potential (BPND) of the ligand in the limbic, executive, and sensorimotor striatal functional subregions, and in the pallidum. BPND estimates were compared between patients and controls while controlling for age and gender. BPND correlations were examined with behavioral and clinical measures, along with regional glutamate levels quantified by the magnetic resonance spectroscopy. Study results Multivariate analysis of covariance demonstrated a significant main effect of diagnosis on BPND (p = .03). A posthoc test showed a trend-level higher sensorimotor striatal BPND in patients, although it did not survive multiple comparison corrections. BPND in controls in this subregion was significantly and negatively correlated with the Tower of London scores, a cognitive subtest. Striatal or dorsolateral prefrontal glutamate levels did not correlate significantly with BPND in either group. Conclusions The results suggest altered striatal PDE10A availability and associated local neural dysfunctions in patients with schizophrenia." @default.
• W4310600302 created "2022-12-12" @default.
• W4310600302 creator A5000844496 @default.
• W4310600302 creator A5001695445 @default.
• W4310600302 creator A5002819177 @default.
• W4310600302 creator A5009790212 @default.
• W4310600302 creator A5023585260 @default.
• W4310600302 creator A5026143979 @default.
• W4310600302 creator A5030087345 @default.
• W4310600302 creator A5033868555 @default.
• W4310600302 creator A5039084458 @default.
• W4310600302 creator A5046005888 @default.
• W4310600302 creator A5048387675 @default.
• W4310600302 creator A5057023665 @default.
• W4310600302 creator A5060847562 @default.
• W4310600302 creator A5064403117 @default.
• W4310600302 creator A5065111183 @default.
• W4310600302 creator A5065587946 @default.
• W4310600302 creator A5079225739 @default.
• W4310600302 date "2022-12-02" @default.
• W4310600302 modified "2023-10-17" @default.
• W4310600302 title "Positron Emission Tomography Assessments of Phosphodiesterase 10A in Patients With Schizophrenia" @default.
• W4310600302 cites W1473714080 @default.
• W4310600302 cites W1621815751 @default.
• W4310600302 cites W1667532483 @default.
• W4310600302 cites W1901260206 @default.
• W4310600302 cites W1969601547 @default.
• W4310600302 cites W1973931941 @default.
• W4310600302 cites W1988786263 @default.
• W4310600302 cites W2004293194 @default.
• W4310600302 cites W2008062633 @default.
• W4310600302 cites W2029037348 @default.
• W4310600302 cites W2036330056 @default.
• W4310600302 cites W2047016005 @default.
• W4310600302 cites W2064649856 @default.
• W4310600302 cites W2067788315 @default.
• W4310600302 cites W2072857392 @default.
• W4310600302 cites W2094134651 @default.
• W4310600302 cites W2096833562 @default.
• W4310600302 cites W2111642689 @default.
• W4310600302 cites W2117671988 @default.
• W4310600302 cites W2118462346 @default.
• W4310600302 cites W2130392097 @default.
• W4310600302 cites W2130835939 @default.
• W4310600302 cites W2140606211 @default.
• W4310600302 cites W2143850783 @default.
• W4310600302 cites W2150857753 @default.
• W4310600302 cites W2171800484 @default.
• W4310600302 cites W2280580658 @default.
• W4310600302 cites W2322521449 @default.
• W4310600302 cites W2342109997 @default.
• W4310600302 cites W2537564630 @default.
• W4310600302 cites W2593649648 @default.
• W4310600302 cites W2594247009 @default.
• W4310600302 cites W2748490300 @default.
• W4310600302 cites W2887124281 @default.
• W4310600302 cites W2889742508 @default.
• W4310600302 cites W2906768105 @default.
• W4310600302 cites W2911962930 @default.
• W4310600302 cites W2911994974 @default.
• W4310600302 cites W3089019757 @default.
• W4310600302 cites W3097374989 @default.
• W4310600302 cites W3161810358 @default.
• W4310600302 cites W4241221200 @default.
• W4310600302 cites W4254775916 @default.
• W4310600302 doi "https://doi.org/10.1093/schbul/sbac181" @default.
• W4310600302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36458958" @default.
• W4310600302 hasPublicationYear "2022" @default.
• W4310600302 type Work @default.
• W4310600302 citedByCount "0" @default.
• W4310600302 crossrefType "journal-article" @default.
• W4310600302 hasAuthorship W4310600302A5000844496 @default.
• W4310600302 hasAuthorship W4310600302A5001695445 @default.
• W4310600302 hasAuthorship W4310600302A5002819177 @default.
• W4310600302 hasAuthorship W4310600302A5009790212 @default.
• W4310600302 hasAuthorship W4310600302A5023585260 @default.
• W4310600302 hasAuthorship W4310600302A5026143979 @default.
• W4310600302 hasAuthorship W4310600302A5030087345 @default.
• W4310600302 hasAuthorship W4310600302A5033868555 @default.
• W4310600302 hasAuthorship W4310600302A5039084458 @default.
• W4310600302 hasAuthorship W4310600302A5046005888 @default.
• W4310600302 hasAuthorship W4310600302A5048387675 @default.
• W4310600302 hasAuthorship W4310600302A5057023665 @default.
• W4310600302 hasAuthorship W4310600302A5060847562 @default.
• W4310600302 hasAuthorship W4310600302A5064403117 @default.
• W4310600302 hasAuthorship W4310600302A5065111183 @default.
• W4310600302 hasAuthorship W4310600302A5065587946 @default.
• W4310600302 hasAuthorship W4310600302A5079225739 @default.
• W4310600302 hasBestOaLocation W43106003021 @default.
• W4310600302 hasConcept C118552586 @default.
• W4310600302 hasConcept C126322002 @default.
• W4310600302 hasConcept C134018914 @default.
• W4310600302 hasConcept C137183658 @default.
• W4310600302 hasConcept C15744967 @default.
• W4310600302 hasConcept C169760540 @default.
• W4310600302 hasConcept C170457331 @default.
• W4310600302 hasConcept C170493617 @default.
• W4310600302 hasConcept C181199279 @default.

• next