FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310600480> ?p ?o ?g. }

• W4310600480 endingPage "15383" @default.
• W4310600480 startingPage "15372" @default.
• W4310600480 abstract "Nanodiscs are broadly used for characterization of membrane proteins as they are generally assumed to provide a near-native environment. In fact, it is an open question whether the physical properties of lipids in nanodiscs and membrane vesicles of the same lipid composition are identical. Here, we investigate the properties of lipids (1,2-dipalmitoyl-sn-glycero-3-phosphocholine, 1,2-dilauroyl-sn-glycero-3-phosphocholine, and their mixtures) in two different sample types, nanodiscs and multilamellar vesicles, by means of spin-label electron spin resonance techniques. Our results provide a quantitative description of lipid dynamics and ordering, elucidating the molecular details of how lipids in the two sample types behave differently in response to temperature and lipid composition. We show that the properties of lipids are altered in nanodiscs such that the dissimilarity of the fluid and gel lipid phases is reduced, and the first-order phase transitions are largely abolished in nanodiscs. We unveil that the ensemble of lipids in the middle of a nanodisc bilayer, as probed by the end-chain spin-label 16-PC, is promoted to a state close to a miscibility critical point, thereby rendering the phase transitions continuous. Critical phenomena have recently been proposed to explain features of the heterogeneity in native cell membranes. Our results lay the groundwork for how to establish a near-native environment in nanodiscs with simple organization of lipid components." @default.
• W4310600480 created "2022-12-12" @default.
• W4310600480 creator A5006611629 @default.
• W4310600480 creator A5016328080 @default.
• W4310600480 creator A5045819956 @default.
• W4310600480 creator A5047273213 @default.
• W4310600480 creator A5049271701 @default.
• W4310600480 creator A5091824929 @default.
• W4310600480 date "2022-12-01" @default.
• W4310600480 modified "2023-10-16" @default.
• W4310600480 title "Nanodisc Lipids Exhibit Singular Behaviors Implying Critical Phenomena" @default.
• W4310600480 cites W1557464334 @default.
• W4310600480 cites W1598629441 @default.
• W4310600480 cites W1966716345 @default.
• W4310600480 cites W1975696535 @default.
• W4310600480 cites W1979952786 @default.
• W4310600480 cites W1982974851 @default.
• W4310600480 cites W1987033415 @default.
• W4310600480 cites W2002197521 @default.
• W4310600480 cites W2004899462 @default.
• W4310600480 cites W2006752983 @default.
• W4310600480 cites W2006986579 @default.
• W4310600480 cites W2011892517 @default.
• W4310600480 cites W2041803307 @default.
• W4310600480 cites W2045827091 @default.
• W4310600480 cites W2050719403 @default.
• W4310600480 cites W2060728272 @default.
• W4310600480 cites W2064910975 @default.
• W4310600480 cites W2069712112 @default.
• W4310600480 cites W2070317388 @default.
• W4310600480 cites W2083767996 @default.
• W4310600480 cites W2097829197 @default.
• W4310600480 cites W2098513990 @default.
• W4310600480 cites W2101304860 @default.
• W4310600480 cites W2128677332 @default.
• W4310600480 cites W2133805329 @default.
• W4310600480 cites W2139874778 @default.
• W4310600480 cites W2150454633 @default.
• W4310600480 cites W2154925541 @default.
• W4310600480 cites W2416828046 @default.
• W4310600480 cites W2587450560 @default.
• W4310600480 cites W2605819511 @default.
• W4310600480 cites W2618951225 @default.
• W4310600480 cites W2621338256 @default.
• W4310600480 cites W2736102926 @default.
• W4310600480 cites W2751124369 @default.
• W4310600480 cites W2896857834 @default.
• W4310600480 cites W2898422481 @default.
• W4310600480 cites W2901159170 @default.
• W4310600480 cites W2913254604 @default.
• W4310600480 cites W2924141382 @default.
• W4310600480 cites W2990552556 @default.
• W4310600480 cites W2999836262 @default.
• W4310600480 cites W3004494148 @default.
• W4310600480 cites W3044541941 @default.
• W4310600480 cites W3044705201 @default.
• W4310600480 cites W3046854096 @default.
• W4310600480 cites W3100994328 @default.
• W4310600480 cites W3101530215 @default.
• W4310600480 cites W3107525545 @default.
• W4310600480 cites W3165610805 @default.
• W4310600480 cites W3186763960 @default.
• W4310600480 cites W3204971563 @default.
• W4310600480 cites W3205393838 @default.
• W4310600480 cites W4234094017 @default.
• W4310600480 doi "https://doi.org/10.1021/acs.langmuir.2c02596" @default.
• W4310600480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36454955" @default.
• W4310600480 hasPublicationYear "2022" @default.
• W4310600480 type Work @default.
• W4310600480 citedByCount "1" @default.
• W4310600480 crossrefType "journal-article" @default.
• W4310600480 hasAuthorship W4310600480A5006611629 @default.
• W4310600480 hasAuthorship W4310600480A5016328080 @default.
• W4310600480 hasAuthorship W4310600480A5045819956 @default.
• W4310600480 hasAuthorship W4310600480A5047273213 @default.
• W4310600480 hasAuthorship W4310600480A5049271701 @default.
• W4310600480 hasAuthorship W4310600480A5091824929 @default.
• W4310600480 hasConcept C110884469 @default.
• W4310600480 hasConcept C12554922 @default.
• W4310600480 hasConcept C130316041 @default.
• W4310600480 hasConcept C159467904 @default.
• W4310600480 hasConcept C178790620 @default.
• W4310600480 hasConcept C185592680 @default.
• W4310600480 hasConcept C2780880673 @default.
• W4310600480 hasConcept C39944091 @default.
• W4310600480 hasConcept C41625074 @default.
• W4310600480 hasConcept C521977710 @default.
• W4310600480 hasConcept C55493867 @default.
• W4310600480 hasConcept C76564549 @default.
• W4310600480 hasConcept C8010536 @default.
• W4310600480 hasConcept C86803240 @default.
• W4310600480 hasConceptScore W4310600480C110884469 @default.
• W4310600480 hasConceptScore W4310600480C12554922 @default.
• W4310600480 hasConceptScore W4310600480C130316041 @default.
• W4310600480 hasConceptScore W4310600480C159467904 @default.
• W4310600480 hasConceptScore W4310600480C178790620 @default.
• W4310600480 hasConceptScore W4310600480C185592680 @default.
• W4310600480 hasConceptScore W4310600480C2780880673 @default.

• next