FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310603203> ?p ?o ?g. }

• W4310603203 abstract "The androgen receptor (AR) plays an essential role in prostate cancer progression and is a key target for prostate cancer treatment. However, patients with prostate cancer undergoing androgen deprivation therapy eventually experience biochemical relapse, with hormone-sensitive prostate cancer progressing into castration-resistant prostate cancer (CRPC). The widespread application of secondary antiandrogens, such as enzalutamide, indicates that targeting AR remains the most efficient method for CRPC treatment. Unfortunately, neither can block AR signaling thoroughly, leading to AR reactivation within several months. Here, we report an approach for suppressing reactivated AR signaling in the CRPC stage. A combination of the protein phosphatase 1 subunit α (PP1α)-specific inhibitor tautomycin and enzalutamide synergistically inhibited cell proliferation and AR signaling in LNCaP and C4-2 cells, as well as in AR variant-positive 22RV1 cells. Our results revealed that enzalutamide competed with residual androgens in CRPC, enhancing tautomycin-mediated AR degradation. In addition, the remaining competitive inhibitory role of enzalutamide on AR facilitated tautomycin-induced AR degradation in 22RV1 cells, further decreasing ARv7 levels via a full-length AR/ARv7 interaction. Taken together, our findings suggest that the combination of tautomycin and enzalutamide could achieve a more comprehensive inhibition of AR signaling in CRPC. AR degraders combined with AR antagonists may represent a new therapeutic strategy for CRPC." @default.
• W4310603203 created "2022-12-12" @default.
• W4310603203 creator A5001329905 @default.
• W4310603203 creator A5009917728 @default.
• W4310603203 creator A5017993003 @default.
• W4310603203 creator A5023559188 @default.
• W4310603203 creator A5036658104 @default.
• W4310603203 creator A5036660919 @default.
• W4310603203 creator A5058542589 @default.
• W4310603203 creator A5081675173 @default.
• W4310603203 date "2022-11-29" @default.
• W4310603203 modified "2023-10-08" @default.
• W4310603203 title "Tautomycin and enzalutamide combination yields synergistic effects on castration-resistant prostate cancer" @default.
• W4310603203 cites W1968786809 @default.
• W4310603203 cites W1969952491 @default.
• W4310603203 cites W1980181290 @default.
• W4310603203 cites W1990287298 @default.
• W4310603203 cites W1993251792 @default.
• W4310603203 cites W1999608828 @default.
• W4310603203 cites W2017839954 @default.
• W4310603203 cites W2041708814 @default.
• W4310603203 cites W2064293531 @default.
• W4310603203 cites W2069741812 @default.
• W4310603203 cites W2077438659 @default.
• W4310603203 cites W2083926838 @default.
• W4310603203 cites W2087818316 @default.
• W4310603203 cites W2090075034 @default.
• W4310603203 cites W2097226696 @default.
• W4310603203 cites W2107633226 @default.
• W4310603203 cites W2109445022 @default.
• W4310603203 cites W2110151487 @default.
• W4310603203 cites W2119504728 @default.
• W4310603203 cites W2130189600 @default.
• W4310603203 cites W2148643283 @default.
• W4310603203 cites W2149131962 @default.
• W4310603203 cites W2165782799 @default.
• W4310603203 cites W2171450779 @default.
• W4310603203 cites W2172339060 @default.
• W4310603203 cites W2181283187 @default.
• W4310603203 cites W2193713074 @default.
• W4310603203 cites W2340799873 @default.
• W4310603203 cites W2409568753 @default.
• W4310603203 cites W2412945422 @default.
• W4310603203 cites W2559738633 @default.
• W4310603203 cites W2595758682 @default.
• W4310603203 cites W2778765825 @default.
• W4310603203 cites W2781525129 @default.
• W4310603203 cites W2883077013 @default.
• W4310603203 cites W2888204653 @default.
• W4310603203 cites W2890428002 @default.
• W4310603203 cites W2891532655 @default.
• W4310603203 cites W2928567438 @default.
• W4310603203 cites W2966112499 @default.
• W4310603203 cites W3111735680 @default.
• W4310603203 doi "https://doi.org/10.1038/s41420-022-01257-1" @default.
• W4310603203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36446767" @default.
• W4310603203 hasPublicationYear "2022" @default.
• W4310603203 type Work @default.
• W4310603203 citedByCount "1" @default.
• W4310603203 countsByYear W43106032032023 @default.
• W4310603203 crossrefType "journal-article" @default.
• W4310603203 hasAuthorship W4310603203A5001329905 @default.
• W4310603203 hasAuthorship W4310603203A5009917728 @default.
• W4310603203 hasAuthorship W4310603203A5017993003 @default.
• W4310603203 hasAuthorship W4310603203A5023559188 @default.
• W4310603203 hasAuthorship W4310603203A5036658104 @default.
• W4310603203 hasAuthorship W4310603203A5036660919 @default.
• W4310603203 hasAuthorship W4310603203A5058542589 @default.
• W4310603203 hasAuthorship W4310603203A5081675173 @default.
• W4310603203 hasBestOaLocation W43106032031 @default.
• W4310603203 hasConcept C121608353 @default.
• W4310603203 hasConcept C126322002 @default.
• W4310603203 hasConcept C185592680 @default.
• W4310603203 hasConcept C2776551883 @default.
• W4310603203 hasConcept C2779723316 @default.
• W4310603203 hasConcept C2780192828 @default.
• W4310603203 hasConcept C502942594 @default.
• W4310603203 hasConcept C61367390 @default.
• W4310603203 hasConcept C71924100 @default.
• W4310603203 hasConcept C98274493 @default.
• W4310603203 hasConceptScore W4310603203C121608353 @default.
• W4310603203 hasConceptScore W4310603203C126322002 @default.
• W4310603203 hasConceptScore W4310603203C185592680 @default.
• W4310603203 hasConceptScore W4310603203C2776551883 @default.
• W4310603203 hasConceptScore W4310603203C2779723316 @default.
• W4310603203 hasConceptScore W4310603203C2780192828 @default.
• W4310603203 hasConceptScore W4310603203C502942594 @default.
• W4310603203 hasConceptScore W4310603203C61367390 @default.
• W4310603203 hasConceptScore W4310603203C71924100 @default.
• W4310603203 hasConceptScore W4310603203C98274493 @default.
• W4310603203 hasIssue "1" @default.
• W4310603203 hasLocation W43106032031 @default.
• W4310603203 hasLocation W43106032032 @default.
• W4310603203 hasLocation W43106032033 @default.
• W4310603203 hasOpenAccess W4310603203 @default.
• W4310603203 hasPrimaryLocation W43106032031 @default.
• W4310603203 hasRelatedWork W2442795568 @default.
• W4310603203 hasRelatedWork W2503901337 @default.
• W4310603203 hasRelatedWork W2806156214 @default.
• W4310603203 hasRelatedWork W2889369899 @default.

• next