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• W4310611442 endingPage "1485" @default.
• W4310611442 startingPage "1473" @default.
• W4310611442 abstract "SARS-CoV-2 3C-like protease (3CLpro), a potential therapeutic target for COVID-19, consists of a chymotrypsin fold and a C-terminal α-helical domain (domain III), the latter of which mediates dimerization required for catalytic activation. To gain further understanding of the functional dynamics of SARS-CoV-2 3CLpro, this review extends the scope to the comparative study of many crystal structures of proteases having the chymotrypsin fold (clan PA of the MEROPS database). First, the close correspondence between the zymogen-enzyme transformation in chymotrypsin and the allosteric dimerization activation in SARS-CoV-2 3CLpro is illustrated. Then, it is shown that the 3C-like proteases of family Coronaviridae (the protease family C30), which are closely related to SARS-CoV-2 3CLpro, have the same homodimeric structure and common activation mechanism via domain III mediated dimerization. The survey extended to order Nidovirales reveals that all 3C-like proteases belonging to Nidovirales have domain III, but with various chain lengths, and 3CLpro of family Mesoniviridae (family C107) has the same homodimeric structure as that of C30, even though they have no sequence similarity. As a reference, monomeric 3C proteases belonging to the more distant family Picornaviridae (family C3) lacking domain III are compared with C30, and it is shown that the 3C proteases are rigid enough to maintain their structures in the active state.The online version contains supplementary material available at 10.1007/s12551-022-01020-x." @default.
• W4310611442 created "2022-12-13" @default.
• W4310611442 creator A5021942420 @default.
• W4310611442 creator A5060225962 @default.
• W4310611442 creator A5067499258 @default.
• W4310611442 creator A5069786759 @default.
• W4310611442 date "2022-12-01" @default.
• W4310611442 modified "2023-09-26" @default.
• W4310611442 title "Functional dynamics of SARS-CoV-2 3C-like protease as a member of clan PA" @default.
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• W4310611442 doi "https://doi.org/10.1007/s12551-022-01020-x" @default.
• W4310611442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36474932" @default.
• W4310611442 hasPublicationYear "2022" @default.
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