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- W4310655959 abstract "<h3>Purpose</h3> Oncoplastic surgical procedures are increasingly being performed in patients undergoing breast conserving surgery (BCS). Due to distortion of breast tissue in breast conserving oncoplastic surgery (BCOS), APBI becomes very challenging. The literature on APBI in BCOS is extremely limited. The aim of our study was to analyze the results of interstitial brachytherapy based APBI in early breast cancer patients who underwent BCOS. <h3>Methods and Materials</h3> Between the period from Jan 2015 to Dec 2020, all patients who underwent APBI following BCS + Type 1 oncoplasty were retrospectively analyzed. Patients with other than Type 1 oncoplastic surgery were excluded from this analysis. The APBI was performed with free hand interstitial brachytherapy implant. CT Scan based treatment planning was done and a HDR dose of 35 Gy/10 fractions/ 5 days (two fractions a day) was prescribed for APBI. Patients were kept on regular follow up for assessing local control and cosmesis. <h3>Results</h3> A total of 60 patients were treated with APBI following BCOS procedure. Median age of the patients was 52 years (range 42-63 years). The median tumor size was 2.5 cm (1-3.5 cm). All the patients were pathological node negative. An average of 11 interstitial brachytherapy catheters were inserted using 2-3 planes. For all patients, dose homogeneity index (DHI) ranged from 0.62-0.92 with a median of 0.84. Median follow-up of entire cohort of patients was 34 months (range 6-84 months). Two patients had ipsilateral breast recurrence and one had systemic metastases. All the patients were alive at the time of analysis. Good-excellent cosmesis was observed in 85% patients. <h3>Conclusion</h3> Our short-term clinical results suggest that interstitial brachytherapy based accelerated partial breast irradiation is feasible after Type 1 oncoplastic breast conserving surgery in selected patients with early breast cancer." @default.
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- W4310655959 date "2022-11-01" @default.
- W4310655959 modified "2023-09-28" @default.
- W4310655959 title "MSPP04 Presentation Time: 4:30 PM" @default.
- W4310655959 doi "https://doi.org/10.1016/j.brachy.2022.09.040" @default.
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