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- W4310668875 abstract "Human mucosal-associated invariant T (MAIT) cells are characterized by their expression of an invariant TCR α chain Vα7.2-Jα33/Jα20/Jα12 paired with a restricted TCR β chain. MAIT cells recognize microbial peptides presented by the highly conserved MHC class I-like molecule MR1 and bridge the innate and acquired immune systems to mediate augmented immune responses. Upon activation, MAIT cells rapidly proliferate, produce a variety of cytokines and cytotoxic molecules, and trigger efficient antitumor immunity. Administration of a representative MAIT cell ligand 5-OP-RU effectively activates MAIT cells and enhances their antitumor capacity. In this review, we introduce MAIT cell biology and their importance in antitumor immunity, summarize the current development of peripheral blood mononuclear cell-derived and stem cell-derived MAIT cell products for cancer treatment, and discuss the potential of genetic engineering of MAIT cells for off-the-shelf cancer immunotherapy." @default.
- W4310668875 created "2022-12-15" @default.
- W4310668875 creator A5002532497 @default.
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- W4310668875 creator A5057602473 @default.
- W4310668875 creator A5079923948 @default.
- W4310668875 creator A5006490641 @default.
- W4310668875 date "2023-03-01" @default.
- W4310668875 modified "2023-10-13" @default.
- W4310668875 title "Mucosal-associated invariant T cells for cancer immunotherapy" @default.
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