FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310690218> ?p ?o ?g. }

• W4310690218 abstract "Abstract Chronic non-healing wounds, an important complication of diabetes, are associated with increased mortality in patients afflicted with this disease. Excessive accumulation of M1 macrophages in diabetic wounds promotes inflammation and results in dysregulated tissue repair. Adipose tissue macrophages (ATMs) derived from healthy lean donors have the abilities to improve glucose tolerance and insulin sensitivity, and modulate inflammation. MiRNAs (miRs), which can be packaged into exosomes (Exos) and secreted from cells, serve as essential regulators of macrophage polarization. Here, we reveal that adipose tissue macrophages (ATMs) isolated from lean mice secrete miR-containing Exos, which modulate macrophage polarization and promote rapid diabetic wound healing when administered to diabetes-prone db/db mice. MiRs sequence of tissue samples from wounds treated with Exos secreted by lean ATMs (ATM-Exos) revealed that miR-222-3p was upregulated. Further analyses showed that inhibition of miR-222-3p using miR inhibitor impaired the macrophage-reprogramming effect of lean ATM-Exos. In the excisional skin wound mouse model, locally inhibiting miR-222-3p disrupted healing dynamics and failed to modulate macrophage polarization. Mechanistic studies revealed a link between miR-222-3p; Bcl2l11/Bim, an inflammatory response effector; macrophage polarization; and diabetic wound healing. In summary, lean ATM-Exos act as positive regulators of macrophage polarization by regulating miR levels in wounds and accelerating wound healing and thus have important implications for wound management in diabetes." @default.
• W4310690218 created "2022-12-15" @default.
• W4310690218 creator A5004305315 @default.
• W4310690218 creator A5006704938 @default.
• W4310690218 creator A5013104816 @default.
• W4310690218 creator A5046938486 @default.
• W4310690218 creator A5052752229 @default.
• W4310690218 creator A5060307236 @default.
• W4310690218 creator A5077118648 @default.
• W4310690218 date "2022-12-05" @default.
• W4310690218 modified "2023-09-27" @default.
• W4310690218 title "Lean Adipose Tissue Macrophage Derived Exosome Confers Immunoregulation to Improve Wound Healing in Diabetes" @default.
• W4310690218 cites W1577305427 @default.
• W4310690218 cites W1913879859 @default.
• W4310690218 cites W1969806743 @default.
• W4310690218 cites W1975355918 @default.
• W4310690218 cites W1999507007 @default.
• W4310690218 cites W2047563937 @default.
• W4310690218 cites W2057217096 @default.
• W4310690218 cites W2214858649 @default.
• W4310690218 cites W2216947660 @default.
• W4310690218 cites W2298890574 @default.
• W4310690218 cites W2301044272 @default.
• W4310690218 cites W2543278676 @default.
• W4310690218 cites W2563017338 @default.
• W4310690218 cites W2598155126 @default.
• W4310690218 cites W2640452423 @default.
• W4310690218 cites W2741105523 @default.
• W4310690218 cites W2758187157 @default.
• W4310690218 cites W2769957434 @default.
• W4310690218 cites W2776403397 @default.
• W4310690218 cites W2782754314 @default.
• W4310690218 cites W2811276814 @default.
• W4310690218 cites W2883082447 @default.
• W4310690218 cites W2891983638 @default.
• W4310690218 cites W2900798880 @default.
• W4310690218 cites W2900976549 @default.
• W4310690218 cites W2916903506 @default.
• W4310690218 cites W2919748437 @default.
• W4310690218 cites W2962755997 @default.
• W4310690218 cites W2965314815 @default.
• W4310690218 cites W2978687867 @default.
• W4310690218 cites W3016404739 @default.
• W4310690218 cites W3021867869 @default.
• W4310690218 cites W3045131948 @default.
• W4310690218 cites W3099641675 @default.
• W4310690218 cites W3115196011 @default.
• W4310690218 cites W3118609716 @default.
• W4310690218 cites W3120374468 @default.
• W4310690218 cites W3127295600 @default.
• W4310690218 cites W3160480924 @default.
• W4310690218 cites W3168732619 @default.
• W4310690218 cites W3194808340 @default.
• W4310690218 cites W3197980203 @default.
• W4310690218 cites W3215218082 @default.
• W4310690218 cites W4205463264 @default.
• W4310690218 cites W4206799195 @default.
• W4310690218 cites W4280504106 @default.
• W4310690218 doi "https://doi.org/10.21203/rs.3.rs-2323072/v1" @default.
• W4310690218 hasPublicationYear "2022" @default.
• W4310690218 type Work @default.
• W4310690218 citedByCount "0" @default.
• W4310690218 crossrefType "posted-content" @default.
• W4310690218 hasAuthorship W4310690218A5004305315 @default.
• W4310690218 hasAuthorship W4310690218A5006704938 @default.
• W4310690218 hasAuthorship W4310690218A5013104816 @default.
• W4310690218 hasAuthorship W4310690218A5046938486 @default.
• W4310690218 hasAuthorship W4310690218A5052752229 @default.
• W4310690218 hasAuthorship W4310690218A5060307236 @default.
• W4310690218 hasAuthorship W4310690218A5077118648 @default.
• W4310690218 hasBestOaLocation W43106902181 @default.
• W4310690218 hasConcept C104317684 @default.
• W4310690218 hasConcept C126322002 @default.
• W4310690218 hasConcept C127561419 @default.
• W4310690218 hasConcept C134018914 @default.
• W4310690218 hasConcept C145059251 @default.
• W4310690218 hasConcept C151955695 @default.
• W4310690218 hasConcept C171089720 @default.
• W4310690218 hasConcept C17675752 @default.
• W4310690218 hasConcept C202751555 @default.
• W4310690218 hasConcept C203014093 @default.
• W4310690218 hasConcept C20518536 @default.
• W4310690218 hasConcept C2776682551 @default.
• W4310690218 hasConcept C2776914184 @default.
• W4310690218 hasConcept C2779244956 @default.
• W4310690218 hasConcept C2780269544 @default.
• W4310690218 hasConcept C2781261824 @default.
• W4310690218 hasConcept C2910375186 @default.
• W4310690218 hasConcept C502942594 @default.
• W4310690218 hasConcept C55493867 @default.
• W4310690218 hasConcept C555293320 @default.
• W4310690218 hasConcept C71924100 @default.
• W4310690218 hasConcept C86803240 @default.
• W4310690218 hasConcept C95444343 @default.
• W4310690218 hasConceptScore W4310690218C104317684 @default.
• W4310690218 hasConceptScore W4310690218C126322002 @default.
• W4310690218 hasConceptScore W4310690218C127561419 @default.
• W4310690218 hasConceptScore W4310690218C134018914 @default.
• W4310690218 hasConceptScore W4310690218C145059251 @default.
• W4310690218 hasConceptScore W4310690218C151955695 @default.

• next