Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310693265> ?p ?o ?g. }
- W4310693265 endingPage "1345" @default.
- W4310693265 startingPage "1336" @default.
- W4310693265 abstract "Connective tissue growth factor (Ctgf) is a matricellular protein with diverse biological function. It is regarded as a central regulator of tissue fibrosis and collagen synthesis in mammals. However, its roles in fish remain elusive. Here, a ctgf gene was cloned (NcCtgf), characterized and functionally studied in the chu's croaker (Nibea coibor). NcCtgf encoded a protein containing 346 amino acids, 38 conserved cysteine residues, 4 functional domains and a signal peptide. NcCtgf shared highest identity (99.4 %) to the Larimichthys crocea Ctgf protein. Phylogenetic tree revealed that NcCtgf clustered with the teleost Ctgfa and Ctgf of higher vertebrates, instead of teleost Ctgfb. NcCtgf was expressed with higher level in gonad, spleen, gill and swimming bladder than other tissues, and was up-regulated in swim bladder synchronously with collagen I genes by hydroxyproline and TGF-β1 treatment. NcCtgf knockdown/overexpression inhibited/promoted collagen synthesis in swim bladder cell, respectively. Notably, NcCtgf protein could be secreted to cell culture medium and up-regulated collagen I expression in swim bladder cell. These findings indicate NcCtgf plays vital roles in collagen synthesis in swim bladder of Nibea coibor, and provide basis for further understanding of ctgf evolution and exploring new approach for enhancing collagen deposition in fish products during aquaculture." @default.
- W4310693265 created "2022-12-15" @default.
- W4310693265 creator A5021687717 @default.
- W4310693265 creator A5028434683 @default.
- W4310693265 creator A5049533744 @default.
- W4310693265 creator A5050364761 @default.
- W4310693265 creator A5070115697 @default.
- W4310693265 creator A5081566414 @default.
- W4310693265 creator A5084905573 @default.
- W4310693265 date "2023-02-01" @default.
- W4310693265 modified "2023-10-16" @default.
- W4310693265 title "Characterization and role of connective tissue growth factor gene in collagen synthesis in swim bladder of chu's croaker (Nibea coibor)" @default.
- W4310693265 cites W1551915675 @default.
- W4310693265 cites W1963681955 @default.
- W4310693265 cites W1971010914 @default.
- W4310693265 cites W1978608615 @default.
- W4310693265 cites W1979076069 @default.
- W4310693265 cites W1982987870 @default.
- W4310693265 cites W1997397312 @default.
- W4310693265 cites W2004763128 @default.
- W4310693265 cites W2015761641 @default.
- W4310693265 cites W2041041342 @default.
- W4310693265 cites W2056564376 @default.
- W4310693265 cites W2060163874 @default.
- W4310693265 cites W2064912476 @default.
- W4310693265 cites W2107277218 @default.
- W4310693265 cites W2110613845 @default.
- W4310693265 cites W2116323280 @default.
- W4310693265 cites W2154035365 @default.
- W4310693265 cites W2159430501 @default.
- W4310693265 cites W2162465592 @default.
- W4310693265 cites W2169883682 @default.
- W4310693265 cites W2474861953 @default.
- W4310693265 cites W2547783103 @default.
- W4310693265 cites W2606062902 @default.
- W4310693265 cites W2617612285 @default.
- W4310693265 cites W2789491433 @default.
- W4310693265 cites W2790111030 @default.
- W4310693265 cites W2794375896 @default.
- W4310693265 cites W2806312038 @default.
- W4310693265 cites W2896382036 @default.
- W4310693265 cites W2898185912 @default.
- W4310693265 cites W2954662965 @default.
- W4310693265 cites W2998589014 @default.
- W4310693265 cites W3002258215 @default.
- W4310693265 cites W3007651380 @default.
- W4310693265 cites W3026663883 @default.
- W4310693265 cites W3204630276 @default.
- W4310693265 cites W4225315695 @default.
- W4310693265 cites W4281643475 @default.
- W4310693265 doi "https://doi.org/10.1016/j.ijbiomac.2022.12.010" @default.
- W4310693265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36473534" @default.
- W4310693265 hasPublicationYear "2023" @default.
- W4310693265 type Work @default.
- W4310693265 citedByCount "1" @default.
- W4310693265 countsByYear W43106932652023 @default.
- W4310693265 crossrefType "journal-article" @default.
- W4310693265 hasAuthorship W4310693265A5021687717 @default.
- W4310693265 hasAuthorship W4310693265A5028434683 @default.
- W4310693265 hasAuthorship W4310693265A5049533744 @default.
- W4310693265 hasAuthorship W4310693265A5050364761 @default.
- W4310693265 hasAuthorship W4310693265A5070115697 @default.
- W4310693265 hasAuthorship W4310693265A5081566414 @default.
- W4310693265 hasAuthorship W4310693265A5084905573 @default.
- W4310693265 hasConcept C104317684 @default.
- W4310693265 hasConcept C153911025 @default.
- W4310693265 hasConcept C170493617 @default.
- W4310693265 hasConcept C173396325 @default.
- W4310693265 hasConcept C189165786 @default.
- W4310693265 hasConcept C2775893135 @default.
- W4310693265 hasConcept C2775960820 @default.
- W4310693265 hasConcept C2780631158 @default.
- W4310693265 hasConcept C2909208804 @default.
- W4310693265 hasConcept C35730697 @default.
- W4310693265 hasConcept C505870484 @default.
- W4310693265 hasConcept C518705261 @default.
- W4310693265 hasConcept C54355233 @default.
- W4310693265 hasConcept C55493867 @default.
- W4310693265 hasConcept C86803240 @default.
- W4310693265 hasConcept C95444343 @default.
- W4310693265 hasConceptScore W4310693265C104317684 @default.
- W4310693265 hasConceptScore W4310693265C153911025 @default.
- W4310693265 hasConceptScore W4310693265C170493617 @default.
- W4310693265 hasConceptScore W4310693265C173396325 @default.
- W4310693265 hasConceptScore W4310693265C189165786 @default.
- W4310693265 hasConceptScore W4310693265C2775893135 @default.
- W4310693265 hasConceptScore W4310693265C2775960820 @default.
- W4310693265 hasConceptScore W4310693265C2780631158 @default.
- W4310693265 hasConceptScore W4310693265C2909208804 @default.
- W4310693265 hasConceptScore W4310693265C35730697 @default.
- W4310693265 hasConceptScore W4310693265C505870484 @default.
- W4310693265 hasConceptScore W4310693265C518705261 @default.
- W4310693265 hasConceptScore W4310693265C54355233 @default.
- W4310693265 hasConceptScore W4310693265C55493867 @default.
- W4310693265 hasConceptScore W4310693265C86803240 @default.
- W4310693265 hasConceptScore W4310693265C95444343 @default.
- W4310693265 hasLocation W43106932651 @default.
- W4310693265 hasLocation W43106932652 @default.