FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310693675> ?p ?o ?g. }

• W4310693675 endingPage "16" @default.
• W4310693675 startingPage "11" @default.
• W4310693675 abstract "Many regions of Africa have experienced lower COVID-19 morbidity and mortality than Europe. Pre-existing humoral responses to endemic human coronaviruses (HCoV) may cross-protect against SARS-CoV-2. We investigated the neutralizing capacity of SARS-CoV-2 spike reactive and nonreactive immunoglobulin (Ig)G and IgA antibodies in prepandemic samples.To investigate the presence of pre-existing immunity, we performed enzyme-linked immunosorbent assay using spike antigens from reference SARS-CoV-2, HCoV HKU1, OC43, NL63, and 229E using prepandemic samples from Kilifi in coastal Kenya. In addition, we performed neutralization assays using pseudotyped reference SARS-CoV-2 to determine the functionality of the identified reactive antibodies.We demonstrate the presence of HCoV serum IgG and mucosal IgA antibodies, which cross-react with the SARS-CoV-2 spike. We show pseudotyped reference SARS-CoV-2 neutralization by prepandemic serum, with a mean infective dose 50 of 1: 251, which is 10-fold less than that of the pooled convalescent sera from patients with COVID-19 but still within predicted protection levels. The prepandemic naso-oropharyngeal fluid neutralized pseudo-SARS-CoV-2 at a mean infective dose 50 of 1: 5.9 in the neutralization assay.Our data provide evidence for pre-existing functional humoral responses to SARS-CoV-2 in Kilifi, coastal Kenya and adds to data showing pre-existing immunity for COVID-19 from other regions." @default.
• W4310693675 created "2022-12-15" @default.
• W4310693675 creator A5000793343 @default.
• W4310693675 creator A5009075899 @default.
• W4310693675 creator A5012731669 @default.
• W4310693675 creator A5013578249 @default.
• W4310693675 creator A5013961861 @default.
• W4310693675 creator A5020679457 @default.
• W4310693675 creator A5037073910 @default.
• W4310693675 creator A5040183990 @default.
• W4310693675 creator A5048950576 @default.
• W4310693675 creator A5051553404 @default.
• W4310693675 creator A5052001803 @default.
• W4310693675 creator A5059822645 @default.
• W4310693675 creator A5069992901 @default.
• W4310693675 creator A5073485372 @default.
• W4310693675 creator A5074780862 @default.
• W4310693675 creator A5083853693 @default.
• W4310693675 creator A5084846253 @default.
• W4310693675 creator A5087452041 @default.
• W4310693675 creator A5089192522 @default.
• W4310693675 creator A5089797891 @default.
• W4310693675 date "2023-02-01" @default.
• W4310693675 modified "2023-10-16" @default.
• W4310693675 title "Serum immunoglobulin G and mucosal immunoglobulin A antibodies from prepandemic samples collected in Kilifi, Kenya, neutralize SARS-CoV-2 in vitro" @default.
• W4310693675 cites W1993150792 @default.
• W4310693675 cites W2212640525 @default.
• W4310693675 cites W2256756668 @default.
• W4310693675 cites W2465777822 @default.
• W4310693675 cites W2750464792 @default.
• W4310693675 cites W3001897055 @default.
• W4310693675 cites W3012650581 @default.
• W4310693675 cites W3014552539 @default.
• W4310693675 cites W3017288557 @default.
• W4310693675 cites W3025320502 @default.
• W4310693675 cites W3031139335 @default.
• W4310693675 cites W3042183476 @default.
• W4310693675 cites W3045971896 @default.
• W4310693675 cites W3047159181 @default.
• W4310693675 cites W3080182479 @default.
• W4310693675 cites W3087128437 @default.
• W4310693675 cites W3096867322 @default.
• W4310693675 cites W3099989333 @default.
• W4310693675 cites W3104471981 @default.
• W4310693675 cites W3112028440 @default.
• W4310693675 cites W3132283266 @default.
• W4310693675 cites W3148454121 @default.
• W4310693675 cites W3161511556 @default.
• W4310693675 cites W3163785571 @default.
• W4310693675 cites W3173236106 @default.
• W4310693675 cites W3190750829 @default.
• W4310693675 cites W3199394488 @default.
• W4310693675 cites W3215251263 @default.
• W4310693675 cites W4200033584 @default.
• W4310693675 cites W4212918871 @default.
• W4310693675 cites W4220869197 @default.
• W4310693675 cites W4282914372 @default.
• W4310693675 cites W4285388105 @default.
• W4310693675 cites W4295206851 @default.
• W4310693675 cites W4295720420 @default.
• W4310693675 doi "https://doi.org/10.1016/j.ijid.2022.11.041" @default.
• W4310693675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36476349" @default.
• W4310693675 hasPublicationYear "2023" @default.
• W4310693675 type Work @default.
• W4310693675 citedByCount "3" @default.
• W4310693675 countsByYear W43106936752022 @default.
• W4310693675 countsByYear W43106936752023 @default.
• W4310693675 crossrefType "journal-article" @default.
• W4310693675 hasAuthorship W4310693675A5000793343 @default.
• W4310693675 hasAuthorship W4310693675A5009075899 @default.
• W4310693675 hasAuthorship W4310693675A5012731669 @default.
• W4310693675 hasAuthorship W4310693675A5013578249 @default.
• W4310693675 hasAuthorship W4310693675A5013961861 @default.
• W4310693675 hasAuthorship W4310693675A5020679457 @default.
• W4310693675 hasAuthorship W4310693675A5037073910 @default.
• W4310693675 hasAuthorship W4310693675A5040183990 @default.
• W4310693675 hasAuthorship W4310693675A5048950576 @default.
• W4310693675 hasAuthorship W4310693675A5051553404 @default.
• W4310693675 hasAuthorship W4310693675A5052001803 @default.
• W4310693675 hasAuthorship W4310693675A5059822645 @default.
• W4310693675 hasAuthorship W4310693675A5069992901 @default.
• W4310693675 hasAuthorship W4310693675A5073485372 @default.
• W4310693675 hasAuthorship W4310693675A5074780862 @default.
• W4310693675 hasAuthorship W4310693675A5083853693 @default.
• W4310693675 hasAuthorship W4310693675A5084846253 @default.
• W4310693675 hasAuthorship W4310693675A5087452041 @default.
• W4310693675 hasAuthorship W4310693675A5089192522 @default.
• W4310693675 hasAuthorship W4310693675A5089797891 @default.
• W4310693675 hasBestOaLocation W43106936751 @default.
• W4310693675 hasConcept C126322002 @default.
• W4310693675 hasConcept C14086860 @default.
• W4310693675 hasConcept C147483822 @default.
• W4310693675 hasConcept C159047783 @default.
• W4310693675 hasConcept C159654299 @default.
• W4310693675 hasConcept C203014093 @default.
• W4310693675 hasConcept C2776548049 @default.
• W4310693675 hasConcept C2776553844 @default.
• W4310693675 hasConcept C2779134260 @default.

• next