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• W4310700814 abstract "Commensal bacteria in the host body play a fundamental role in the differentiation and maintenance of the immune system. Studies on intestinal immunity have revealed that, under steady-state conditions, microflora have an important role in the maintenance of health. However, the role of oral commensal bacteria on the oral immune system is still unclear. Here, we clarify the interactions between commensal bacteria and the oral mucosal immune system under steady-state conditions.We used germ-free mice that had never been exposed to bacteria and conventional mice grown with normal bacterial flora. Oral cells were isolated from the oral mucosa, stained with specific antibodies, and analyzed by flow cytometry. For the detection of myeloperoxidase and intracellular cytokines, oral cells were stimulated with N-formyl-methionine-leucyl-phenylalanine and phorbol 12-myristate 13-acetate/ionomycin, respectively.We found that the oral mucosa harbored more neutrophils in germ-free mice than in conventional mice. However, the majority of neutrophils in the germ-free oral mucosa exhibited an immature phenotype. Other immune cells, including macrophages, T cells, and B cells, in the oral mucosa of germ-free mice showed similar differentiation to those in conventional mice. These results indicate that in the steady-state oral mucosa, the normal commensal flora promote the peripheral differentiation of neutrophils.The presence of commensal flora is critical for the development of adequate immune system in the oral mucosa." @default.
• W4310700814 created "2022-12-16" @default.
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• W4310700814 date "2023-03-01" @default.
• W4310700814 modified "2023-09-29" @default.
• W4310700814 title "Oral commensal bacterial flora is responsible for peripheral differentiation of neutrophils in the oral mucosa in the steady state" @default.
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• W4310700814 doi "https://doi.org/10.1016/j.job.2022.11.002" @default.
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