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• W4310703793 abstract "The current study was designed to investigate the potential anti-inflammatory and antioxidant effects of fingolimod against Ovalbumin (Ova)-induced allergic airway inflammation compared to dexamethasone. Fingolimod was given (0.5 mg/kg/day, p.o.) for sensitized mice 1 h before Ova challenge from Days 19 to 24. Fingolimod significantly inhibited Ova-induced elevation of inflammatory cells and eosinophils numbers in bronchoalveolar lavage fluid (BALF) and reduced concentrations of immunoglobulin E in serum and of sphingosine-1-phosphate, interleukin (IL)-4, and IL-13 in BALF. Fingolimod inhibited microvascular leakage and edema as reflected by the decreased lung/body weight index. These findings were supported by histopathological examination results showing that fingolimod substantially decreased perivascular edema and inflammatory cell infiltration. Fingolimod also attenuated Ova-induced oxidative stress as evidenced by decreased malondialdehyde concentration along with increasing concentrations of reduced glutathione and superoxide dismutase in lung tissues. Fingolimod also significantly decreased monocyte chemoattractant protein-1 (MCP-1), p-ERK, and p-P38 in lung tissues of Ova-challenged mice. In conclusion, the current study demonstrated the anti-inflammatory and antioxidant effects of fingolimod in allergic airway inflammation that might be associated with the downregulation of mitogen activated kinases signaling to decrease T helper 2 cytokine secretion (IL-4 and IL-13) and MCP-1 expression, along with the inhibition of oxidative stress." @default.
• W4310703793 created "2022-12-16" @default.
• W4310703793 creator A5039549420 @default.
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• W4310703793 date "2022-12-05" @default.
• W4310703793 modified "2023-09-26" @default.
• W4310703793 title "Fingolimod attenuates ovalbumin‐induced airway inflammation via inhibiting MAPK/ERK signaling in mice" @default.
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• W4310703793 doi "https://doi.org/10.1002/jbt.23266" @default.
• W4310703793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36468814" @default.
• W4310703793 hasPublicationYear "2022" @default.
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