Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310704553> ?p ?o ?g. }
- W4310704553 abstract "Deep brain stimulation (DBS) has been investigated for neuropsychiatric disorders. In this phase 1 trial, we treated four posttraumatic stress disorder (PTSD) patients with DBS delivered to the subgenual cingulum and the uncinate fasciculus. In addition to validated clinical scales, patients underwent neuroimaging studies and psychophysiological assessments of fear conditioning, extinction, and recall. We show that the procedure is safe and potentially effective (55% reduction in Clinical Administered PTSD Scale scores). Posttreatment imaging data revealed metabolic activity changes in PTSD neurocircuits. During psychophysiological assessments, patients with PTSD had higher skin conductance responses when tested for recall compared to healthy controls. After DBS, this objectively measured variable was significantly reduced. Last, we found that a ratio between recall of extinguished and nonextinguished conditioned responses had a strong correlation with clinical outcome. As this variable was recorded at baseline, it may comprise a potential biomarker of treatment response." @default.
- W4310704553 created "2022-12-16" @default.
- W4310704553 creator A5008214582 @default.
- W4310704553 creator A5016242504 @default.
- W4310704553 creator A5023782543 @default.
- W4310704553 creator A5036040848 @default.
- W4310704553 creator A5043096690 @default.
- W4310704553 creator A5046675273 @default.
- W4310704553 creator A5056005902 @default.
- W4310704553 creator A5058507775 @default.
- W4310704553 creator A5059604177 @default.
- W4310704553 creator A5067783855 @default.
- W4310704553 creator A5082966395 @default.
- W4310704553 creator A5083933184 @default.
- W4310704553 creator A5090699665 @default.
- W4310704553 date "2022-12-02" @default.
- W4310704553 modified "2023-09-26" @default.
- W4310704553 title "Deep brain stimulation of the subgenual cingulum and uncinate fasciculus for the treatment of posttraumatic stress disorder" @default.
- W4310704553 cites W1965965542 @default.
- W4310704553 cites W1970353033 @default.
- W4310704553 cites W1977723029 @default.
- W4310704553 cites W1988072750 @default.
- W4310704553 cites W1995782021 @default.
- W4310704553 cites W2000402944 @default.
- W4310704553 cites W2000929270 @default.
- W4310704553 cites W2011525076 @default.
- W4310704553 cites W2012392799 @default.
- W4310704553 cites W2014786844 @default.
- W4310704553 cites W2027154295 @default.
- W4310704553 cites W2028072116 @default.
- W4310704553 cites W2049812132 @default.
- W4310704553 cites W2069416181 @default.
- W4310704553 cites W2072296702 @default.
- W4310704553 cites W2072595271 @default.
- W4310704553 cites W2103558642 @default.
- W4310704553 cites W2108888119 @default.
- W4310704553 cites W2114214919 @default.
- W4310704553 cites W2117526650 @default.
- W4310704553 cites W2121648229 @default.
- W4310704553 cites W2122410839 @default.
- W4310704553 cites W2122823008 @default.
- W4310704553 cites W2124152744 @default.
- W4310704553 cites W2127485482 @default.
- W4310704553 cites W2132098276 @default.
- W4310704553 cites W2132969335 @default.
- W4310704553 cites W2133265147 @default.
- W4310704553 cites W2136086850 @default.
- W4310704553 cites W2136145485 @default.
- W4310704553 cites W2137226568 @default.
- W4310704553 cites W2140594127 @default.
- W4310704553 cites W2147969224 @default.
- W4310704553 cites W2153353924 @default.
- W4310704553 cites W2160741333 @default.
- W4310704553 cites W2161118302 @default.
- W4310704553 cites W2163749372 @default.
- W4310704553 cites W2163849648 @default.
- W4310704553 cites W2212699615 @default.
- W4310704553 cites W2213369915 @default.
- W4310704553 cites W2257615813 @default.
- W4310704553 cites W2273698149 @default.
- W4310704553 cites W2316851676 @default.
- W4310704553 cites W2503910289 @default.
- W4310704553 cites W2522302102 @default.
- W4310704553 cites W2522772114 @default.
- W4310704553 cites W2522839134 @default.
- W4310704553 cites W2560977591 @default.
- W4310704553 cites W2589284845 @default.
- W4310704553 cites W2606960287 @default.
- W4310704553 cites W2607453530 @default.
- W4310704553 cites W2751434469 @default.
- W4310704553 cites W2752725072 @default.
- W4310704553 cites W2763173694 @default.
- W4310704553 cites W2767738832 @default.
- W4310704553 cites W2776295999 @default.
- W4310704553 cites W2777987555 @default.
- W4310704553 cites W2782340352 @default.
- W4310704553 cites W2950023299 @default.
- W4310704553 cites W2977883299 @default.
- W4310704553 cites W3039854619 @default.
- W4310704553 cites W3080423983 @default.
- W4310704553 cites W3112583445 @default.
- W4310704553 cites W3125756598 @default.
- W4310704553 cites W4206418155 @default.
- W4310704553 cites W4213316025 @default.
- W4310704553 cites W4286111422 @default.
- W4310704553 doi "https://doi.org/10.1126/sciadv.adc9970" @default.
- W4310704553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36459550" @default.
- W4310704553 hasPublicationYear "2022" @default.
- W4310704553 type Work @default.
- W4310704553 citedByCount "3" @default.
- W4310704553 countsByYear W43107045532023 @default.
- W4310704553 crossrefType "journal-article" @default.
- W4310704553 hasAuthorship W4310704553A5008214582 @default.
- W4310704553 hasAuthorship W4310704553A5016242504 @default.
- W4310704553 hasAuthorship W4310704553A5023782543 @default.
- W4310704553 hasAuthorship W4310704553A5036040848 @default.
- W4310704553 hasAuthorship W4310704553A5043096690 @default.
- W4310704553 hasAuthorship W4310704553A5046675273 @default.
- W4310704553 hasAuthorship W4310704553A5056005902 @default.
- W4310704553 hasAuthorship W4310704553A5058507775 @default.