Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310705095> ?p ?o ?g. }
- W4310705095 endingPage "182" @default.
- W4310705095 startingPage "159" @default.
- W4310705095 abstract "Multiparametric quantitative imaging biomarkers (QIBs) offer distinct advantages over single, univariate descriptors because they provide a more complete measure of complex, multidimensional biological systems. In disease, where structural and functional disturbances occur across a multitude of subsystems, multivariate QIBs are needed to measure the extent of system malfunction. This paper, the first Use Case in a series of articles on multiparameter imaging biomarkers, considers multiple QIBs as a multidimensional vector to represent all relevant disease constructs more completely. The approach proposed offers several advantages over QIBs as multiple endpoints and avoids combining them into a single composite that obscures the medical meaning of the individual measurements. We focus on establishing statistically rigorous methods to create a single, simultaneous measure from multiple QIBs that preserves the sensitivity of each univariate QIB while incorporating the correlation among QIBs. Details are provided for metrological methods to quantify the technical performance. Methods to reduce the set of QIBs, test the superiority of the mp-QIB model to any univariate QIB model, and design study strategies for generating precision and validity claims are also provided. QIBs of Alzheimer's Disease from the ADNI merge data set are used as a case study to illustrate the methods described." @default.
- W4310705095 created "2022-12-16" @default.
- W4310705095 creator A5009955603 @default.
- W4310705095 creator A5010642871 @default.
- W4310705095 creator A5011172657 @default.
- W4310705095 creator A5020812264 @default.
- W4310705095 creator A5033315037 @default.
- W4310705095 creator A5033439953 @default.
- W4310705095 creator A5044303900 @default.
- W4310705095 creator A5056394743 @default.
- W4310705095 creator A5060445631 @default.
- W4310705095 creator A5084960775 @default.
- W4310705095 creator A5086399744 @default.
- W4310705095 date "2023-02-01" @default.
- W4310705095 modified "2023-10-16" @default.
- W4310705095 title "Multiparametric Quantitative Imaging Biomarker as a Multivariate Descriptor of Health: A Roadmap" @default.
- W4310705095 cites W1035761246 @default.
- W4310705095 cites W105144345 @default.
- W4310705095 cites W1814296497 @default.
- W4310705095 cites W1834986685 @default.
- W4310705095 cites W1933023737 @default.
- W4310705095 cites W1965555277 @default.
- W4310705095 cites W1967727095 @default.
- W4310705095 cites W1967951742 @default.
- W4310705095 cites W1969869918 @default.
- W4310705095 cites W1972093502 @default.
- W4310705095 cites W1978284123 @default.
- W4310705095 cites W1978933628 @default.
- W4310705095 cites W1988013567 @default.
- W4310705095 cites W1992165995 @default.
- W4310705095 cites W1993571512 @default.
- W4310705095 cites W1994011595 @default.
- W4310705095 cites W1998005104 @default.
- W4310705095 cites W2001536791 @default.
- W4310705095 cites W2003094610 @default.
- W4310705095 cites W2004439558 @default.
- W4310705095 cites W2008119444 @default.
- W4310705095 cites W2008750507 @default.
- W4310705095 cites W2010501098 @default.
- W4310705095 cites W2018350398 @default.
- W4310705095 cites W2021544883 @default.
- W4310705095 cites W2028170711 @default.
- W4310705095 cites W2028590696 @default.
- W4310705095 cites W2028748733 @default.
- W4310705095 cites W2033980725 @default.
- W4310705095 cites W2036141548 @default.
- W4310705095 cites W2036602956 @default.
- W4310705095 cites W2040937200 @default.
- W4310705095 cites W2045435052 @default.
- W4310705095 cites W2047261231 @default.
- W4310705095 cites W2048489440 @default.
- W4310705095 cites W2054285148 @default.
- W4310705095 cites W2062764004 @default.
- W4310705095 cites W2071381562 @default.
- W4310705095 cites W2072484199 @default.
- W4310705095 cites W2096861478 @default.
- W4310705095 cites W2100420142 @default.
- W4310705095 cites W2100563697 @default.
- W4310705095 cites W2104398861 @default.
- W4310705095 cites W2105084079 @default.
- W4310705095 cites W2109095034 @default.
- W4310705095 cites W2109938573 @default.
- W4310705095 cites W2110957729 @default.
- W4310705095 cites W2117913805 @default.
- W4310705095 cites W2119147717 @default.
- W4310705095 cites W2122328291 @default.
- W4310705095 cites W2122376319 @default.
- W4310705095 cites W2122912498 @default.
- W4310705095 cites W2123534406 @default.
- W4310705095 cites W2126541486 @default.
- W4310705095 cites W2127841934 @default.
- W4310705095 cites W2131900456 @default.
- W4310705095 cites W2138839431 @default.
- W4310705095 cites W2147881931 @default.
- W4310705095 cites W2151608875 @default.
- W4310705095 cites W2159887611 @default.
- W4310705095 cites W2164085284 @default.
- W4310705095 cites W2289648316 @default.
- W4310705095 cites W2334272338 @default.
- W4310705095 cites W2520389576 @default.
- W4310705095 cites W2546804000 @default.
- W4310705095 cites W2553908354 @default.
- W4310705095 cites W2577001291 @default.
- W4310705095 cites W2591651461 @default.
- W4310705095 cites W2598700764 @default.
- W4310705095 cites W2617459693 @default.
- W4310705095 cites W2625950084 @default.
- W4310705095 cites W2736804501 @default.
- W4310705095 cites W2753210178 @default.
- W4310705095 cites W2757169940 @default.
- W4310705095 cites W2783923767 @default.
- W4310705095 cites W2896665945 @default.
- W4310705095 cites W2900570413 @default.
- W4310705095 cites W2931870777 @default.
- W4310705095 cites W2964503732 @default.
- W4310705095 cites W2980857002 @default.
- W4310705095 cites W2996412902 @default.
- W4310705095 cites W2998585275 @default.