FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310705293> ?p ?o ?g. }

• W4310705293 endingPage "3015" @default.
• W4310705293 startingPage "2988" @default.
• W4310705293 abstract "Liver is one of the most important and complex organs in the human body, being characterized by a sophisticated microarchitecture and responsible for key physiological functions. Despite its remarkable ability to regenerate, acute liver failure and chronic liver diseases are major causes of morbidity and mortality worldwide. Therefore, understanding the molecular mechanisms underlying such liver disorders is critical for the successful development of novel therapeutics. In this frame, preclinical animal models have been portrayed as the most commonly used tool to address such issues. However, due to significant species differences in liver architecture, regenerative capacity, disease progression, inflammatory markers, metabolism rates, and drug response, animal models cannot fully recapitulate the complexity of human liver metabolism. As a result, translational research to model human liver diseases and drug screening platforms may yield limited results, leading to failure scenarios. To overcome this impasse, over the last decade, 3D human liver in vitro models have been proposed as an alternative to pre-clinical animal models. These systems have been successfully employed for the investigation of the etiology and dynamics of liver diseases, for drug screening, and - more recently - to design patient-tailored therapies, resulting in potentially higher efficacy and reduced costs compared to other methods. Here, we review the most recent advances in this rapidly evolving field with particular attention to organoid cultures, liver-on-a-chip platforms, and engineered scaffold-based approaches." @default.
• W4310705293 created "2022-12-16" @default.
• W4310705293 creator A5002402089 @default.
• W4310705293 creator A5003147758 @default.
• W4310705293 creator A5006345411 @default.
• W4310705293 creator A5018520218 @default.
• W4310705293 creator A5038925906 @default.
• W4310705293 creator A5046261220 @default.
• W4310705293 creator A5051697713 @default.
• W4310705293 creator A5069538965 @default.
• W4310705293 creator A5082514712 @default.
• W4310705293 creator A5087846050 @default.
• W4310705293 creator A5089680987 @default.
• W4310705293 date "2023-01-01" @default.
• W4310705293 modified "2023-10-15" @default.
• W4310705293 title "<i>In vitro</i> functional models for human liver diseases and drug screening: beyond animal testing" @default.
• W4310705293 cites W1154526730 @default.
• W4310705293 cites W1632817672 @default.
• W4310705293 cites W1669332385 @default.
• W4310705293 cites W1797606584 @default.
• W4310705293 cites W1862651181 @default.
• W4310705293 cites W1929730131 @default.
• W4310705293 cites W1967822239 @default.
• W4310705293 cites W1968934048 @default.
• W4310705293 cites W1977665282 @default.
• W4310705293 cites W1988075836 @default.
• W4310705293 cites W1995916543 @default.
• W4310705293 cites W2000151960 @default.
• W4310705293 cites W2001023527 @default.
• W4310705293 cites W2003142831 @default.
• W4310705293 cites W2010165954 @default.
• W4310705293 cites W2012867417 @default.
• W4310705293 cites W2017783406 @default.
• W4310705293 cites W2018286352 @default.
• W4310705293 cites W2019350759 @default.
• W4310705293 cites W2022941161 @default.
• W4310705293 cites W2031785809 @default.
• W4310705293 cites W2038202065 @default.
• W4310705293 cites W2038998535 @default.
• W4310705293 cites W2041309288 @default.
• W4310705293 cites W2041356700 @default.
• W4310705293 cites W2044928246 @default.
• W4310705293 cites W2048473946 @default.
• W4310705293 cites W2048644480 @default.
• W4310705293 cites W2052569069 @default.
• W4310705293 cites W2052787315 @default.
• W4310705293 cites W2059091110 @default.
• W4310705293 cites W2059347990 @default.
• W4310705293 cites W2069118366 @default.
• W4310705293 cites W2076860792 @default.
• W4310705293 cites W2078023703 @default.
• W4310705293 cites W2081605536 @default.
• W4310705293 cites W2084141237 @default.
• W4310705293 cites W2084515183 @default.
• W4310705293 cites W2086172466 @default.
• W4310705293 cites W2088295987 @default.
• W4310705293 cites W2094392052 @default.
• W4310705293 cites W2096502099 @default.
• W4310705293 cites W2099361891 @default.
• W4310705293 cites W2099536383 @default.
• W4310705293 cites W2101601223 @default.
• W4310705293 cites W2113042424 @default.
• W4310705293 cites W2115609745 @default.
• W4310705293 cites W2132551021 @default.
• W4310705293 cites W2134208433 @default.
• W4310705293 cites W2139053048 @default.
• W4310705293 cites W2141577002 @default.
• W4310705293 cites W2150586142 @default.
• W4310705293 cites W2157929811 @default.
• W4310705293 cites W2160501566 @default.
• W4310705293 cites W2162870084 @default.
• W4310705293 cites W2164548118 @default.
• W4310705293 cites W2165747522 @default.
• W4310705293 cites W2201543151 @default.
• W4310705293 cites W2220809577 @default.
• W4310705293 cites W2221197034 @default.
• W4310705293 cites W2232645088 @default.
• W4310705293 cites W2237642421 @default.
• W4310705293 cites W2264207729 @default.
• W4310705293 cites W2264718512 @default.
• W4310705293 cites W2275458638 @default.
• W4310705293 cites W2319035619 @default.
• W4310705293 cites W2362472408 @default.
• W4310705293 cites W2411101077 @default.
• W4310705293 cites W2415956675 @default.
• W4310705293 cites W2421162826 @default.
• W4310705293 cites W2429685958 @default.
• W4310705293 cites W2462042948 @default.
• W4310705293 cites W2462428454 @default.
• W4310705293 cites W2473248288 @default.
• W4310705293 cites W2513154145 @default.
• W4310705293 cites W2518217943 @default.
• W4310705293 cites W2535870561 @default.
• W4310705293 cites W2563494429 @default.
• W4310705293 cites W2594153159 @default.
• W4310705293 cites W2599959153 @default.
• W4310705293 cites W2600543839 @default.
• W4310705293 cites W2605174594 @default.

• next