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• W4310705771 abstract "Objective: To analyze the association of fasting plasma glucose (FPG) with mild cognitive impairment (MCI) in the Chinese middle-aged and elderly population from four provinces. Methods: Data were drawn from the baseline data of the Community-based Cohort Study on Nervous System Disease 2018-2019. We selected 3 272 subjects aged 55 and above with completed information on demographics, lifestyle, disease history, cognitive test, psychological assessment, and bio-chemistries measurement, and who were capable of performing basic activities of daily living but without Alzheimer's disease during recruitment. A multivariate logistic regression model was employed to analyze the association between FPG and MCI. Results: Median level of FPG in the study population was 5.5 mmol/L. The prevalence of MCI was 24.8%, and those in groups of the FPG quintile were 19.4%, 22.2%, 29.2%, 26.6%, and 26.1%, respectively, which significantly increased the trend (P=0.002). After adjustment of confounders, multivariate logistic regression analysis found that the MCI risk of subjects in the Q3,Q4 and Q5 groups was 1.641 (95%CI: 1.226-2.131), 1.373 (95%CI: 1.036-1.825), 1.402 (95%CI: 1.054-1.871) times as high as that in the Q1 group, respectively. Conclusion: High FPG level might serve as a risk factor for MCI in the middle-aged and elderly population, suggesting the importance of monitoring and controlling plasma glucose even without diabetes.目的： 分析我国4省份中老年人FPG与轻度认知功能障碍（MCI）的关联性。 方法： 利用神经系统疾病专病社区队列研究2018-2019年基线调查数据，选择有完整人口统计学、生活方式、疾病史、认知功能和心理评估及血生化检测数据、有基本日常生活能力且未患阿尔茨海默病的3 272名≥55岁中老年人作为研究对象，采用多因素logistic回归模型分析FPG和MCI的关联性。 结果： 研究人群FPG中位水平为5.5 mmol/L，MCI患病率为24.8%。FPG五等分组的MCI患病率分别为19.4%、22.2%、29.2%、26.6%和26.1%，差异有统计学意义且呈上升趋势（P=0.002）。调整混杂因素后，多因素logistic回归分析结果显示，FPG的Q3、Q4和Q5组中老年人MCI患病风险分别是Q1组的1.641（95%CI：1.226~2.131）、1.373（95%CI：1.036~1.825）和1.402（95%CI：1.054~1.871）倍。 结论： 较高的FPG可能是中老年人MCI的危险因素，提示中老年人即使未患糖尿病，仍应注意监测和控制血糖水平。." @default.
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• W4310705771 date "2022-10-10" @default.
• W4310705771 modified "2023-10-15" @default.
• W4310705771 title "[Association between fasting plasma glucose and mild cognitive impairment in Chinese 55 and older population from four provinces]." @default.
• W4310705771 doi "https://doi.org/10.3760/cma.j.cn112338-20211223-01012" @default.
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