Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310705911> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4310705911 abstract "Acute lung injury (ALI) is a common critical disease, which is characterized by an uncontrolled, acute inflammatory response, diffuse lung damage and ultimately directly deteriorates into acute respiratory distress syndrome. The number of pro-inflammatory macrophages is related to the severity of ALI. Up-regulation of lipopolysaccharide (LPS)-activated macrophage apoptosis can reduce the pro-inflammatory reactions. Jumonji domain-containing protein D3 (JMJD3)-mediated histone 3 lysine 27 trimethylation (H3K27me3) demethylation may promote the pro-inflammatory response of macrophages under LPS stimulation. However, the mechanism of JMJD3 affecting macrophage apoptosis is still not clear. To explore this gap in knowledge, the ALI mice model with intratracheal administration of LPS and RAW264.7 cells with LPS stimulation were used as in vivo and in vitro experiments. The expression of JMJD3 and H3K27me3 and their cellular localization were analysed in lung tissue. Apoptosis was evaluated using TUNEL staining and flow cytometry. Expression of H3K27me3, ADORA2A and C/EBPβ were compared among different treatments and chromatin immunoprecipitation was performed to investigate the regulatory relationship. Our study showed that JMJD3 expression was upregulated in LPS-induced ALI mice and RAW264.7 cells. JMJD3-indued H3K27me3 demethylation inhibited caspase-3 cleavage by upregulating ADORA2A to decrease LPS-stimulated macrophage apoptosis and promoted the inflammatory reaction. This H3K27me3 demethylation also increased C/EBPβ expression, which may enhance ADORA2A expression further. Besides, inhibiting ADORA2A can also promote LPS-limited macrophage apoptosis. Moreover, the inhibition of JMJD3 in vivo and in vitro relieved the inhibition of macrophage apoptosis thus leading to the resolution of the inflammation. JMJD3 might inhibit macrophage apoptosis by promoting ADORA2A expression in LPS-induced ALI." @default.
- W4310705911 created "2022-12-16" @default.
- W4310705911 creator A5042728101 @default.
- W4310705911 creator A5065267477 @default.
- W4310705911 creator A5090728786 @default.
- W4310705911 date "2022-12-01" @default.
- W4310705911 modified "2023-10-09" @default.
- W4310705911 title "H3K27 tri-demethylase JMJD3 inhibits macrophage apoptosis by promoting ADORA2A in lipopolysaccharide-induced acute lung injury" @default.
- W4310705911 cites W1984917888 @default.
- W4310705911 cites W2035964694 @default.
- W4310705911 cites W2041194473 @default.
- W4310705911 cites W2094201102 @default.
- W4310705911 cites W2105420327 @default.
- W4310705911 cites W2109086417 @default.
- W4310705911 cites W2111846773 @default.
- W4310705911 cites W2115144902 @default.
- W4310705911 cites W2121528042 @default.
- W4310705911 cites W2138671479 @default.
- W4310705911 cites W2142268747 @default.
- W4310705911 cites W2157600239 @default.
- W4310705911 cites W2411767485 @default.
- W4310705911 cites W2565647833 @default.
- W4310705911 cites W2570034567 @default.
- W4310705911 cites W2739174192 @default.
- W4310705911 cites W2800734039 @default.
- W4310705911 cites W2808417971 @default.
- W4310705911 cites W2886798607 @default.
- W4310705911 cites W2887230940 @default.
- W4310705911 cites W2894865228 @default.
- W4310705911 cites W2897143284 @default.
- W4310705911 cites W2989544643 @default.
- W4310705911 cites W3001749980 @default.
- W4310705911 cites W3095553221 @default.
- W4310705911 cites W3097513244 @default.
- W4310705911 cites W3108906652 @default.
- W4310705911 cites W3158860161 @default.
- W4310705911 cites W3176580718 @default.
- W4310705911 cites W3179393623 @default.
- W4310705911 cites W3185248974 @default.
- W4310705911 cites W3198353783 @default.
- W4310705911 cites W3207019623 @default.
- W4310705911 cites W3212276855 @default.
- W4310705911 doi "https://doi.org/10.1038/s41420-022-01268-y" @default.
- W4310705911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36456564" @default.
- W4310705911 hasPublicationYear "2022" @default.
- W4310705911 type Work @default.
- W4310705911 citedByCount "0" @default.
- W4310705911 crossrefType "journal-article" @default.
- W4310705911 hasAuthorship W4310705911A5042728101 @default.
- W4310705911 hasAuthorship W4310705911A5065267477 @default.
- W4310705911 hasAuthorship W4310705911A5090728786 @default.
- W4310705911 hasBestOaLocation W43107059111 @default.
- W4310705911 hasConcept C150903083 @default.
- W4310705911 hasConcept C185592680 @default.
- W4310705911 hasConcept C190283241 @default.
- W4310705911 hasConcept C202751555 @default.
- W4310705911 hasConcept C203014093 @default.
- W4310705911 hasConcept C207001950 @default.
- W4310705911 hasConcept C2778012055 @default.
- W4310705911 hasConcept C2778754761 @default.
- W4310705911 hasConcept C2779244956 @default.
- W4310705911 hasConcept C502942594 @default.
- W4310705911 hasConcept C55493867 @default.
- W4310705911 hasConcept C86803240 @default.
- W4310705911 hasConcept C95444343 @default.
- W4310705911 hasConceptScore W4310705911C150903083 @default.
- W4310705911 hasConceptScore W4310705911C185592680 @default.
- W4310705911 hasConceptScore W4310705911C190283241 @default.
- W4310705911 hasConceptScore W4310705911C202751555 @default.
- W4310705911 hasConceptScore W4310705911C203014093 @default.
- W4310705911 hasConceptScore W4310705911C207001950 @default.
- W4310705911 hasConceptScore W4310705911C2778012055 @default.
- W4310705911 hasConceptScore W4310705911C2778754761 @default.
- W4310705911 hasConceptScore W4310705911C2779244956 @default.
- W4310705911 hasConceptScore W4310705911C502942594 @default.
- W4310705911 hasConceptScore W4310705911C55493867 @default.
- W4310705911 hasConceptScore W4310705911C86803240 @default.
- W4310705911 hasConceptScore W4310705911C95444343 @default.
- W4310705911 hasIssue "1" @default.
- W4310705911 hasLocation W43107059111 @default.
- W4310705911 hasLocation W43107059112 @default.
- W4310705911 hasLocation W43107059113 @default.
- W4310705911 hasOpenAccess W4310705911 @default.
- W4310705911 hasPrimaryLocation W43107059111 @default.
- W4310705911 hasRelatedWork W2081615811 @default.
- W4310705911 hasRelatedWork W2177660713 @default.
- W4310705911 hasRelatedWork W2382726111 @default.
- W4310705911 hasRelatedWork W2386214274 @default.
- W4310705911 hasRelatedWork W2394006517 @default.
- W4310705911 hasRelatedWork W2408308257 @default.
- W4310705911 hasRelatedWork W2533674896 @default.
- W4310705911 hasRelatedWork W2947544903 @default.
- W4310705911 hasRelatedWork W2990049546 @default.
- W4310705911 hasRelatedWork W3030745059 @default.
- W4310705911 hasVolume "8" @default.
- W4310705911 isParatext "false" @default.
- W4310705911 isRetracted "false" @default.
- W4310705911 workType "article" @default.