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• W4310705924 abstract "With the increasing use of next-generation sequencing, highly effective targeted therapies have been emerging as treatment options for several cancer types. Recurrent gene-fusions have been recognized in sarcomas; however, options for targeted therapy remain scarce. Here, we describe a case of a sarcoma, associated with a RET::TRIM33-fusion gene with an exceptional response to a neoadjuvant therapy with the selective RET inhibitor selpercatinib. Resected tumor revealed subtotal histopathologic response. This is the first report of successful targeted therapy with selpercatinib in RET-fusion-associated sarcomas. As new targeted therapies are under development, similar treatment options may become available for sarcoma patients." @default.
• W4310705924 created "2022-12-16" @default.
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• W4310705924 date "2022-12-05" @default.
• W4310705924 modified "2023-10-17" @default.
• W4310705924 title "Exceptional response to neoadjuvant targeted therapy with the selective RET inhibitor selpercatinib in RET-fusion-associated sarcoma" @default.
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• W4310705924 doi "https://doi.org/10.1007/s00432-022-04496-y" @default.
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