FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310706736> ?p ?o ?g. }

• W4310706736 endingPage "e1010533" @default.
• W4310706736 startingPage "e1010533" @default.
• W4310706736 abstract "Stress-induced cell death, mainly apoptosis, and its subsequent tissue repair is interlinked although our knowledge of this connection is still very limited. An intriguing finding is apoptosis-induced proliferation (AiP), an evolutionary conserved mechanism employed by apoptotic cells to trigger compensatory proliferation of their neighboring cells. Studies using Drosophila as a model organism have revealed that apoptotic caspases and c-Jun N-terminal kinase (JNK) signaling play critical roles to activate AiP. For example, the initiator caspase Dronc, the caspase-9 ortholog in Drosophila, promotes activation of JNK leading to release of mitogenic signals and AiP. Recent studies further revealed that Dronc relocates to the cell cortex via Myo1D, an unconventional myosin, and stimulates production of reactive oxygen species (ROS) to trigger AiP. During this process, ROS can attract hemocytes, the Drosophila macrophages, which further amplify JNK signaling cell non-autonomously. However, the intrinsic components connecting Dronc, ROS and JNK within the stressed signal-producing cells remain elusive. Here, we identified LIM domain kinase 1 (LIMK1), a kinase promoting cellular F-actin polymerization, as a novel regulator of AiP. F-actin accumulates in a Dronc-dependent manner in response to apoptotic stress. Suppression of F-actin polymerization in stressed cells by knocking down LIMK1 or expressing Cofilin, an inhibitor of F-actin elongation, blocks ROS production and JNK activation, hence AiP. Furthermore, Dronc and LIMK1 genetically interact. Co-expression of Dronc and LIMK1 drives F-actin accumulation, ROS production and JNK activation. Interestingly, these synergistic effects between Dronc and LIMK1 depend on Myo1D. Therefore, F-actin remodeling plays an important role mediating caspase-driven ROS production and JNK activation in the process of AiP." @default.
• W4310706736 created "2022-12-16" @default.
• W4310706736 creator A5027733318 @default.
• W4310706736 creator A5036725638 @default.
• W4310706736 creator A5041181413 @default.
• W4310706736 creator A5050792667 @default.
• W4310706736 creator A5057505029 @default.
• W4310706736 creator A5058365734 @default.
• W4310706736 creator A5079260368 @default.
• W4310706736 date "2022-12-05" @default.
• W4310706736 modified "2023-10-14" @default.
• W4310706736 title "Actin remodeling mediates ROS production and JNK activation to drive apoptosis-induced proliferation" @default.
• W4310706736 cites W1484094963 @default.
• W4310706736 cites W1640813462 @default.
• W4310706736 cites W1939431494 @default.
• W4310706736 cites W1964083798 @default.
• W4310706736 cites W1975523864 @default.
• W4310706736 cites W1981691518 @default.
• W4310706736 cites W1982200083 @default.
• W4310706736 cites W1991049879 @default.
• W4310706736 cites W1993041663 @default.
• W4310706736 cites W2003769148 @default.
• W4310706736 cites W2009440283 @default.
• W4310706736 cites W2012853593 @default.
• W4310706736 cites W2014545259 @default.
• W4310706736 cites W2021772999 @default.
• W4310706736 cites W2022362803 @default.
• W4310706736 cites W2030965765 @default.
• W4310706736 cites W2041629876 @default.
• W4310706736 cites W2043494467 @default.
• W4310706736 cites W2045204908 @default.
• W4310706736 cites W2050468052 @default.
• W4310706736 cites W2062094940 @default.
• W4310706736 cites W2064752586 @default.
• W4310706736 cites W2074519187 @default.
• W4310706736 cites W2081092282 @default.
• W4310706736 cites W2088557523 @default.
• W4310706736 cites W2106442761 @default.
• W4310706736 cites W2109736236 @default.
• W4310706736 cites W2117010634 @default.
• W4310706736 cites W2119205870 @default.
• W4310706736 cites W2124097936 @default.
• W4310706736 cites W2126546276 @default.
• W4310706736 cites W2131934556 @default.
• W4310706736 cites W2138253156 @default.
• W4310706736 cites W2139587743 @default.
• W4310706736 cites W2149956571 @default.
• W4310706736 cites W2151325153 @default.
• W4310706736 cites W2154073936 @default.
• W4310706736 cites W2154481751 @default.
• W4310706736 cites W2160777888 @default.
• W4310706736 cites W2161742793 @default.
• W4310706736 cites W2163964383 @default.
• W4310706736 cites W2165721689 @default.
• W4310706736 cites W2171130969 @default.
• W4310706736 cites W2171572099 @default.
• W4310706736 cites W2284688090 @default.
• W4310706736 cites W2507700403 @default.
• W4310706736 cites W2514723087 @default.
• W4310706736 cites W2584757604 @default.
• W4310706736 cites W2804508541 @default.
• W4310706736 cites W2895967709 @default.
• W4310706736 cites W2899601976 @default.
• W4310706736 cites W3043462158 @default.
• W4310706736 cites W3092324095 @default.
• W4310706736 cites W4250359189 @default.
• W4310706736 cites W51164494 @default.
• W4310706736 doi "https://doi.org/10.1371/journal.pgen.1010533" @default.
• W4310706736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36469525" @default.
• W4310706736 hasPublicationYear "2022" @default.
• W4310706736 type Work @default.
• W4310706736 citedByCount "4" @default.
• W4310706736 countsByYear W43107067362023 @default.
• W4310706736 crossrefType "journal-article" @default.
• W4310706736 hasAuthorship W4310706736A5027733318 @default.
• W4310706736 hasAuthorship W4310706736A5036725638 @default.
• W4310706736 hasAuthorship W4310706736A5041181413 @default.
• W4310706736 hasAuthorship W4310706736A5050792667 @default.
• W4310706736 hasAuthorship W4310706736A5057505029 @default.
• W4310706736 hasAuthorship W4310706736A5058365734 @default.
• W4310706736 hasAuthorship W4310706736A5079260368 @default.
• W4310706736 hasBestOaLocation W43107067361 @default.
• W4310706736 hasConcept C104317684 @default.
• W4310706736 hasConcept C125705527 @default.
• W4310706736 hasConcept C136961756 @default.
• W4310706736 hasConcept C142669718 @default.
• W4310706736 hasConcept C1491633281 @default.
• W4310706736 hasConcept C166703698 @default.
• W4310706736 hasConcept C184235292 @default.
• W4310706736 hasConcept C190283241 @default.
• W4310706736 hasConcept C2776601116 @default.
• W4310706736 hasConcept C2993400109 @default.
• W4310706736 hasConcept C31573885 @default.
• W4310706736 hasConcept C48349386 @default.
• W4310706736 hasConcept C55493867 @default.
• W4310706736 hasConcept C62478195 @default.
• W4310706736 hasConcept C67705224 @default.
• W4310706736 hasConcept C86803240 @default.

• next