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• W4310708975 abstract "Transcranial direct current stimulation (tDCS) has the potential to modulate cognitive training in healthy aging; however, results from various studies have been inconsistent. We hypothesized that inter-individual differences in baseline brain state may contribute to the varied results. We aimed to explore whether baseline resting-state dynamic functional connectivity (rs-dFC) and/or conventional resting-state static functional connectivity (rs-sFC) may be related to the magnitude of cognitive aftereffects of tDCS. To achieve this aim, we used data from our double-blind randomized sham-controlled cross-over tDCS trial in 25 healthy seniors in which bifrontal tDCS combined with cognitive training had induced significant behavioral aftereffects. We performed a backward regression analysis including rs-sFC/rs-dFC measures to explain the variability in the magnitude of tDCS-induced improvements in visual object-matching task (VOMT) accuracy. Rs-dFC analysis revealed four rs-dFC states. The occurrence rate of a rs-dFC state 4, characterized by a high correlation between the left fronto-parietal control network and the language network, was significantly associated with tDCS-induced VOMT accuracy changes. The rs-sFC measure was not significantly associated with the cognitive outcome. We show that flexibility of the brain state representing readiness for top-down control of object identification implicated in the studied task is linked to the tDCS-enhanced task accuracy." @default.
• W4310708975 created "2022-12-16" @default.
• W4310708975 creator A5008404124 @default.
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• W4310708975 creator A5025361514 @default.
• W4310708975 creator A5032197912 @default.
• W4310708975 creator A5088566588 @default.
• W4310708975 date "2022-12-01" @default.
• W4310708975 modified "2023-10-09" @default.
• W4310708975 title "Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS" @default.
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