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• W4310709728 abstract "Abstract Our knowledge about neuronal activity in the sensorimotor cortex relies primarily on stereotyped movements that are strictly controlled in experimental settings. It remains unclear how results can be carried over to less constrained behavior like that of freely moving subjects. Toward this goal, we developed a self-paced behavioral paradigm that encouraged rats to engage in different movement types. We employed bilateral electrophysiological recordings across the entire sensorimotor cortex and simultaneous paw tracking. These techniques revealed behavioral coupling of neurons with lateralization and an anterior–posterior gradient from the premotor to the primary sensory cortex. The structure of population activity patterns was conserved across animals despite the severe under-sampling of the total number of neurons and variations in electrode positions across individuals. We demonstrated cross-subject and cross-session generalization in a decoding task through alignments of low-dimensional neural manifolds, providing evidence of a conserved neuronal code." @default.
• W4310709728 created "2022-12-16" @default.
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• W4310709728 date "2022-12-02" @default.
• W4310709728 modified "2023-10-16" @default.
• W4310709728 title "Conserved structures of neural activity in sensorimotor cortex of freely moving rats allow cross-subject decoding" @default.
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• W4310709728 doi "https://doi.org/10.1038/s41467-022-35115-6" @default.
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• W4310709728 hasPublicationYear "2022" @default.
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