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- W4310713950 abstract "Gout and hyperuricemia are present in 25% and 60% of patients with chronic kidney disease (CKD), respectively. Despite the common association, the role of uric acid in the progression of kidney disease and in metabolic complications remains contested. Some authorities argue that the treatment of asymptomatic hyperuricemia in CKD is not indicated, and some have even suggested hyperuricemia may be beneficial. Here, we review the various arguments both for and against treatment. The weight of the evidence suggests asymptomatic hyperuricemia is likely injurious, but it may primarily relate to subgroups, those who have systemic crystal deposits, those with frequent urinary crystalluria or kidney stones, and those with high intracellular uric acid levels. We recommend carefully designed clinical trials to test if lowering uric acid in hyperuricemic subjects with cardiometabolic complications is protective." @default.
- W4310713950 created "2022-12-16" @default.
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- W4310713950 creator A5055457360 @default.
- W4310713950 creator A5070591787 @default.
- W4310713950 date "2023-02-01" @default.
- W4310713950 modified "2023-10-01" @default.
- W4310713950 title "Uric Acid and Chronic Kidney Disease: Still More to Do" @default.
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