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- W4310723490 abstract "Polyesters composed of hydroxy acids (HAs) and diols serve many material niches and are invaluable to our daily lives. However, their traditional synthesis from petrochemicals creates many environmental concerns. Metabolically engineered microorganisms have been leveraged for the industrially competitive production of a few polyesters with properties that limit their application. Designing new metabolic pathways to polyester building blocks is essential to broadening material property diversity and improving carbon and energy usage of current bioproduction schemes. This review focuses on recently developed pathways to HAs and diols. Specifically, new pathways to 2,3- and ω-Hydroxy acids, as well as C3-C4 and medium-chain-length diols, are discussed. Pathways to the same compound are compared on the basis of criteria such as energy usage, number of pathway steps, and titer. Finally, suggestions for improvements and next steps for each pathway are also discussed." @default.
- W4310723490 created "2022-12-16" @default.
- W4310723490 creator A5000824788 @default.
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- W4310723490 date "2023-02-01" @default.
- W4310723490 modified "2023-10-10" @default.
- W4310723490 title "Engineering polyester monomer diversity through novel pathway design" @default.
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- W4310723490 doi "https://doi.org/10.1016/j.copbio.2022.102852" @default.
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