FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310725957> ?p ?o ?g. }

• W4310725957 endingPage "144" @default.
• W4310725957 startingPage "137" @default.
• W4310725957 abstract "Immune checkpoint inhibitors (ICI) are standard of care in advanced non-small cell lung cancer (NSCLC). However, not all patients benefit, even among PD-L1 tumor proportional score (TPS) ≥50%, indicating an unmet need for additional biomarkers such as those assessing the tumor immune microenvironment (TIME). DetermaIO is a 27-gene assay that classifies TIME and has previously demonstrated association with ICI response.FFPE samples were selected from BC Cancer and West Clinic Cancer Center patients with performance status (PS) ≤2 who received at least 2 cycles of ICI monotherapy in the first (1L) or second line (2L). IO scores were generated and analyzed for association with PFS and OS.In the entire cohort (N=147), IO score was significantly associated with OS (HR=0.68, 95%CI 0.47-0.99, P = .042) and PFS (HR=0.62, 95%CI 0.43-0.88, P = .0069). In 1L treated patients (PD-L1≥50%, N=78), IO score was significantly associated with PFS (HR=0.55, 95%CI 0.32-0.94, P = .028). In exploratory analyses, IO score was associated with benefit in 1L PS2 patients for OS (HR = 0.26, 95%CI 0.091-0.74, P = .012) and PFS (HR = 0.27, 95%CI 0.098-0.72, P = .0095) which was confirmed in PFS subgroup analysis in the independent West Cancer Center study (N=13 HR=0.14, 95%CI 0.027-0.76, P = .023).These data confirm the association of DetermaIO with ICI clinical benefit in NSCLC, and expand on previous studies by demonstrating that first line treated PD-L1≥50% patients can further be stratified by IO score to identify efficacy. Exploratory analysis suggested that the IO score identifies benefit in patients with poor PS." @default.
• W4310725957 created "2022-12-16" @default.
• W4310725957 creator A5005681945 @default.
• W4310725957 creator A5010230522 @default.
• W4310725957 creator A5012341950 @default.
• W4310725957 creator A5033135467 @default.
• W4310725957 creator A5034318098 @default.
• W4310725957 creator A5036091074 @default.
• W4310725957 creator A5048241163 @default.
• W4310725957 creator A5050750573 @default.
• W4310725957 creator A5073189857 @default.
• W4310725957 creator A5075020691 @default.
• W4310725957 creator A5075717157 @default.
• W4310725957 creator A5085745169 @default.
• W4310725957 date "2023-03-01" @default.
• W4310725957 modified "2023-09-30" @default.
• W4310725957 title "27-gene Immuno-Oncology (IO) Score is Associated With Efficacy of Checkpoint Immunotherapy in Advanced NSCLC: A Retrospective BC Cancer Study" @default.
• W4310725957 cites W1981049999 @default.
• W4310725957 cites W2019607817 @default.
• W4310725957 cites W2287133162 @default.
• W4310725957 cites W2895006950 @default.
• W4310725957 cites W2900082702 @default.
• W4310725957 cites W2914335731 @default.
• W4310725957 cites W2937826446 @default.
• W4310725957 cites W2946670461 @default.
• W4310725957 cites W3013239365 @default.
• W4310725957 cites W3024035973 @default.
• W4310725957 cites W3048896255 @default.
• W4310725957 cites W3097803258 @default.
• W4310725957 cites W3126239108 @default.
• W4310725957 cites W3135875378 @default.
• W4310725957 cites W3136487287 @default.
• W4310725957 cites W3152514714 @default.
• W4310725957 cites W3202940825 @default.
• W4310725957 cites W4200509514 @default.
• W4310725957 cites W4206544786 @default.
• W4310725957 cites W4206841660 @default.
• W4310725957 cites W4223924422 @default.
• W4310725957 cites W4234236664 @default.
• W4310725957 cites W4281628511 @default.
• W4310725957 cites W4293029435 @default.
• W4310725957 cites W4293870361 @default.
• W4310725957 doi "https://doi.org/10.1016/j.cllc.2022.11.009" @default.
• W4310725957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36564297" @default.
• W4310725957 hasPublicationYear "2023" @default.
• W4310725957 type Work @default.
• W4310725957 citedByCount "3" @default.
• W4310725957 countsByYear W43107259572023 @default.
• W4310725957 crossrefType "journal-article" @default.
• W4310725957 hasAuthorship W4310725957A5005681945 @default.
• W4310725957 hasAuthorship W4310725957A5010230522 @default.
• W4310725957 hasAuthorship W4310725957A5012341950 @default.
• W4310725957 hasAuthorship W4310725957A5033135467 @default.
• W4310725957 hasAuthorship W4310725957A5034318098 @default.
• W4310725957 hasAuthorship W4310725957A5036091074 @default.
• W4310725957 hasAuthorship W4310725957A5048241163 @default.
• W4310725957 hasAuthorship W4310725957A5050750573 @default.
• W4310725957 hasAuthorship W4310725957A5073189857 @default.
• W4310725957 hasAuthorship W4310725957A5075020691 @default.
• W4310725957 hasAuthorship W4310725957A5075717157 @default.
• W4310725957 hasAuthorship W4310725957A5085745169 @default.
• W4310725957 hasBestOaLocation W43107259571 @default.
• W4310725957 hasConcept C121608353 @default.
• W4310725957 hasConcept C126322002 @default.
• W4310725957 hasConcept C143998085 @default.
• W4310725957 hasConcept C167135981 @default.
• W4310725957 hasConcept C2776256026 @default.
• W4310725957 hasConcept C2777701055 @default.
• W4310725957 hasConcept C2780030458 @default.
• W4310725957 hasConcept C2780057760 @default.
• W4310725957 hasConcept C2780739268 @default.
• W4310725957 hasConcept C2781053074 @default.
• W4310725957 hasConcept C3019894029 @default.
• W4310725957 hasConcept C71924100 @default.
• W4310725957 hasConcept C72563966 @default.
• W4310725957 hasConceptScore W4310725957C121608353 @default.
• W4310725957 hasConceptScore W4310725957C126322002 @default.
• W4310725957 hasConceptScore W4310725957C143998085 @default.
• W4310725957 hasConceptScore W4310725957C167135981 @default.
• W4310725957 hasConceptScore W4310725957C2776256026 @default.
• W4310725957 hasConceptScore W4310725957C2777701055 @default.
• W4310725957 hasConceptScore W4310725957C2780030458 @default.
• W4310725957 hasConceptScore W4310725957C2780057760 @default.
• W4310725957 hasConceptScore W4310725957C2780739268 @default.
• W4310725957 hasConceptScore W4310725957C2781053074 @default.
• W4310725957 hasConceptScore W4310725957C3019894029 @default.
• W4310725957 hasConceptScore W4310725957C71924100 @default.
• W4310725957 hasConceptScore W4310725957C72563966 @default.
• W4310725957 hasIssue "2" @default.
• W4310725957 hasLocation W43107259571 @default.
• W4310725957 hasLocation W43107259572 @default.
• W4310725957 hasOpenAccess W4310725957 @default.
• W4310725957 hasPrimaryLocation W43107259571 @default.
• W4310725957 hasRelatedWork W2751400660 @default.
• W4310725957 hasRelatedWork W2766583070 @default.
• W4310725957 hasRelatedWork W2957427793 @default.
• W4310725957 hasRelatedWork W2962238349 @default.
• W4310725957 hasRelatedWork W2969038597 @default.

• next