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- W4310751119 abstract "Abstract The malaria parasite life cycle includes asexual replication in human blood, with a proportion of parasites differentiating to gametocytes required for transmission to mosquitoes. Commitment to differentiate into gametocytes, which is marked by activation of the parasite transcription factor ap2-g , is known to be influenced by host factors but a comprehensive model remains uncertain. Here we analyze data from 828 children in Kilifi, Kenya with severe, uncomplicated, and asymptomatic malaria infection over 18 years of falling malaria transmission. We examine markers of host immunity and metabolism, and markers of parasite growth and transmission investment. We find that inflammatory responses and reduced plasma lysophosphatidylcholine levels are associated with markers of increased investment in parasite sexual reproduction (i.e., transmission investment) and reduced growth (i.e., asexual replication). This association becomes stronger with falling transmission and suggests that parasites can rapidly respond to the within-host environment, which in turn is subject to changing transmission." @default.
- W4310751119 created "2022-12-17" @default.
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- W4310751119 date "2022-12-02" @default.
- W4310751119 modified "2023-10-15" @default.
- W4310751119 title "<i>Plasmodium falciparum</i>adapts its investment into replication<i>versus</i>transmission according to the host environment" @default.
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- W4310751119 doi "https://doi.org/10.1101/2022.11.29.518379" @default.
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