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- W4310754059 abstract "In patients receiving moderately emetogenic chemotherapy (MEC), antiemetic guidelines lack evidence to recommend an NK1 receptor antagonist (RA) for all patients; therefore, they endorse a 5-HT3 RA + dexamethasone (DEX). However, the NCCN guidelines recognize that this approach is inadequate prophylaxis for many patients and include an NK1 RA-containing option selectively for those with individual emetic risk factors (e.g., prior CINV, age <50, female). Evidence shows that NEPA (a fixed combination of an NK1 RA, (fos)netupitant, and a 5-HT3 RA, palonosetron) is effective in a non-interventional real-world setting (Zelek 2021) in a heterogeneous population of patients with cancer receiving highly emetogenic or MEC and in patients with CINV risk factors." @default.
- W4310754059 created "2022-12-17" @default.
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- W4310754059 date "2022-11-01" @default.
- W4310754059 modified "2023-09-27" @default.
- W4310754059 title "295TiP Assessing the benefit of NEPA (fixed combination of netupitant/palonosetron) for preventing chemotherapy-induced nausea and vomiting (CINV) in patients at increased emetic risk receiving moderately emetogenic chemotherapy" @default.
- W4310754059 doi "https://doi.org/10.1016/j.annonc.2022.10.320" @default.
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