FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310758435> ?p ?o ?g. }

• W4310758435 endingPage "103282" @default.
• W4310758435 startingPage "103282" @default.
• W4310758435 abstract "Enhanced emotional empathy, the ability to share others' affective experiences, can be a feature of Alzheimer's disease (AD), but whether emotional empathy increases in the preclinical phase of the disease is unknown. We measured emotional empathy over time (range = 0 - 7.3 years, mean = 2.4 years) in 86 older adults during a period in which they were cognitively healthy, functionally normal, and free of dementia symptoms. For each participant, we computed longitudinal trajectories for empathic concern (i.e., an other-oriented form of emotional empathy that promotes prosocial actions) and emotional contagion (i.e., a self-focused form of emotional empathy often accompanied by feelings of distress) from informant ratings of participants' empathy on the Interpersonal Reactivity Index. Amyloid-β (Aβ) positron emission tomography (PET) scans were used to classify participants as either Aβ positive (Aβ+, n = 23) or negative (Aβ-, n = 63) based on Aβ-PET cortical binding. Participants also underwent structural and task-free functional magnetic resonance imaging approximately two years on average after their last empathy assessment, at which time most participants remained cognitively healthy. Results indicated that empathic concern, but not emotional contagion, increased more over time in Aβ+ participants than in Aβ- participants despite no initial group difference at the first measurement. Higher connectivity between certain salience network node-pairs (i.e., pregenual anterior cingulate cortex and periaqueductal gray) predicted longitudinal increases in empathic concern in the Aβ+ group but not in the Aβ- group. The Aβ+ participants also had higher overall salience network connectivity than Aβ- participants despite no differences in gray matter volume. These results suggest gains in empathic concern may be a very early feature of AD pathophysiology that relates to hyperconnectivity in the salience network, a system that supports emotion generation and interoception. A better understanding of emotional empathy trajectories in the early stages of AD pathophysiology will broaden the lens on preclinical AD changes and help clinicians to identify older adults who should be screened for AD biomarkers." @default.
• W4310758435 created "2022-12-17" @default.
• W4310758435 creator A5016730229 @default.
• W4310758435 creator A5024419194 @default.
• W4310758435 creator A5025318059 @default.
• W4310758435 creator A5046120768 @default.
• W4310758435 creator A5052536571 @default.
• W4310758435 creator A5060848965 @default.
• W4310758435 creator A5061594637 @default.
• W4310758435 creator A5067452441 @default.
• W4310758435 creator A5074694043 @default.
• W4310758435 creator A5085701239 @default.
• W4310758435 creator A5090632741 @default.
• W4310758435 creator A5090742144 @default.
• W4310758435 date "2023-01-01" @default.
• W4310758435 modified "2023-10-15" @default.
• W4310758435 title "Increasing empathic concern relates to salience network hyperconnectivity in cognitively healthy older adults with elevated amyloid-β burden" @default.
• W4310758435 cites W1517523921 @default.
• W4310758435 cites W1519378085 @default.
• W4310758435 cites W1694363227 @default.
• W4310758435 cites W1778088371 @default.
• W4310758435 cites W1847168837 @default.
• W4310758435 cites W1969227910 @default.
• W4310758435 cites W1969571804 @default.
• W4310758435 cites W1970928383 @default.
• W4310758435 cites W1977714477 @default.
• W4310758435 cites W1978992682 @default.
• W4310758435 cites W1979631864 @default.
• W4310758435 cites W1980083892 @default.
• W4310758435 cites W1980527160 @default.
• W4310758435 cites W1983183519 @default.
• W4310758435 cites W1989222460 @default.
• W4310758435 cites W1990134753 @default.
• W4310758435 cites W1991771535 @default.
• W4310758435 cites W1995296289 @default.
• W4310758435 cites W1995698752 @default.
• W4310758435 cites W2001688761 @default.
• W4310758435 cites W2003473552 @default.
• W4310758435 cites W2003569140 @default.
• W4310758435 cites W2005238835 @default.
• W4310758435 cites W2007318901 @default.
• W4310758435 cites W2007996892 @default.
• W4310758435 cites W2010216178 @default.
• W4310758435 cites W2013391120 @default.
• W4310758435 cites W2015629132 @default.
• W4310758435 cites W2016086578 @default.
• W4310758435 cites W2018342879 @default.
• W4310758435 cites W2018346861 @default.
• W4310758435 cites W2019671076 @default.
• W4310758435 cites W2020044743 @default.
• W4310758435 cites W2020609444 @default.
• W4310758435 cites W2022040401 @default.
• W4310758435 cites W2023331656 @default.
• W4310758435 cites W2023908259 @default.
• W4310758435 cites W2024034758 @default.
• W4310758435 cites W2024398157 @default.
• W4310758435 cites W2033803096 @default.
• W4310758435 cites W2045196028 @default.
• W4310758435 cites W2047453615 @default.
• W4310758435 cites W2050568737 @default.
• W4310758435 cites W2052300396 @default.
• W4310758435 cites W2052742260 @default.
• W4310758435 cites W2058815839 @default.
• W4310758435 cites W2060759363 @default.
• W4310758435 cites W2070624619 @default.
• W4310758435 cites W2071758656 @default.
• W4310758435 cites W2076146317 @default.
• W4310758435 cites W2080847728 @default.
• W4310758435 cites W2083635328 @default.
• W4310758435 cites W2086719660 @default.
• W4310758435 cites W2088046437 @default.
• W4310758435 cites W2090687144 @default.
• W4310758435 cites W2092932101 @default.
• W4310758435 cites W2094001799 @default.
• W4310758435 cites W2096476371 @default.
• W4310758435 cites W2099693452 @default.
• W4310758435 cites W2101334128 @default.
• W4310758435 cites W2102585585 @default.
• W4310758435 cites W2103346709 @default.
• W4310758435 cites W2103717170 @default.
• W4310758435 cites W2104384019 @default.
• W4310758435 cites W2109405824 @default.
• W4310758435 cites W2111420081 @default.
• W4310758435 cites W2111542961 @default.
• W4310758435 cites W2112519660 @default.
• W4310758435 cites W2116146623 @default.
• W4310758435 cites W2116573184 @default.
• W4310758435 cites W2116658855 @default.
• W4310758435 cites W2117237786 @default.
• W4310758435 cites W2117340355 @default.
• W4310758435 cites W2117385529 @default.
• W4310758435 cites W2119848633 @default.
• W4310758435 cites W2122087907 @default.
• W4310758435 cites W2126293656 @default.
• W4310758435 cites W2129497119 @default.
• W4310758435 cites W2129624700 @default.
• W4310758435 cites W2133649359 @default.
• W4310758435 cites W2133903921 @default.

• next