Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310762502> ?p ?o ?g. }
- W4310762502 endingPage "105351" @default.
- W4310762502 startingPage "105351" @default.
- W4310762502 abstract "Alcoholic liver disease (ALD) regarding to liver damage caused by alcohol abuse is characterized by chronic liver inflammation, with dysregulations of the gut microbiota and its metabolites. Accumulating studies has demonstrated that butyrate exhibits pleitropic benefits in chronic metabolic diseases. The present study was designed to investigate the effects and mechanisms of butyrate on ALD. In vivo, C57BL/6J mice were fed with isocaloric modified Lieber-DeCarli liquid diets with or without ethanol which supplemented with sodium butyrate (NaB, 0.6 g/kg) for 6 weeks. In vitro, murine macrophage RAW264.7 were pretreated with NaB or G protein coupled receptor (GPR) 43 antagonist to verify the specific mechanism of NaB effectiveness in LPS-induced inflammatory response. Finally, the routine indexes indicated that NaB treatment significantly alleviated liver injury and lipid deposition, as well as inflammation in ALD mice. On the other hand, M2 macrophage (Mψ) along with its representative enzyme Arg-1, were significantly elevated, whereas M1 Mψ coupled with its marker enzyme iNOS, showed decreased after NaB intervention. Moverover, the expressions of Toll-like receptor 4 (TLR4), nuclear factor-κB (NF-κB), nod-like receptor protein 3 (NLRP3) and caspase-1 were notably decreased with NaB intervention. Intriguingly, the inhibition of GPR43 signals impaired the anti-inflammation effects of NaB. And our further research found that NaB supplementation not only increased the expressions of GPR43 and β-arrstine2 (ARRB2), but also strengthened the interactions between ARRB2 and NLRP3/TAK1 binding protein 1 (TAB1). These results indicated that butyrate may ameliorate ALD by means of modulating Mψ polarization and suppressing LPS-TLR4-NF-κB/NLRP3 axis via mediating GPR43-ARRB2 signaling pathway." @default.
- W4310762502 created "2022-12-17" @default.
- W4310762502 creator A5016748416 @default.
- W4310762502 creator A5034694275 @default.
- W4310762502 creator A5049114928 @default.
- W4310762502 creator A5059358267 @default.
- W4310762502 creator A5064218064 @default.
- W4310762502 creator A5068080767 @default.
- W4310762502 creator A5070812231 @default.
- W4310762502 creator A5071530636 @default.
- W4310762502 creator A5074196854 @default.
- W4310762502 creator A5080102032 @default.
- W4310762502 creator A5086932000 @default.
- W4310762502 date "2022-12-01" @default.
- W4310762502 modified "2023-10-14" @default.
- W4310762502 title "Butyrate ameliorates inflammation of alcoholic liver disease by suppressing the LPS-TLR4-NF-κB/NLRP3 axis via binding GPR43-β-arrestin2" @default.
- W4310762502 cites W1966073473 @default.
- W4310762502 cites W1970136916 @default.
- W4310762502 cites W1986142882 @default.
- W4310762502 cites W1998522372 @default.
- W4310762502 cites W1999906527 @default.
- W4310762502 cites W2002703043 @default.
- W4310762502 cites W2027968599 @default.
- W4310762502 cites W2125932503 @default.
- W4310762502 cites W2131094572 @default.
- W4310762502 cites W2135530906 @default.
- W4310762502 cites W2138915349 @default.
- W4310762502 cites W2144754352 @default.
- W4310762502 cites W2165067288 @default.
- W4310762502 cites W2236332835 @default.
- W4310762502 cites W2259551399 @default.
- W4310762502 cites W2310441748 @default.
- W4310762502 cites W2338740599 @default.
- W4310762502 cites W2338773685 @default.
- W4310762502 cites W2572192644 @default.
- W4310762502 cites W2590249136 @default.
- W4310762502 cites W2619267148 @default.
- W4310762502 cites W2620019493 @default.
- W4310762502 cites W2736346397 @default.
- W4310762502 cites W2765733390 @default.
- W4310762502 cites W2884304683 @default.
- W4310762502 cites W2900192128 @default.
- W4310762502 cites W2907273106 @default.
- W4310762502 cites W2910709942 @default.
- W4310762502 cites W2911808822 @default.
- W4310762502 cites W2914997630 @default.
- W4310762502 cites W2923426205 @default.
- W4310762502 cites W2952767311 @default.
- W4310762502 cites W2964783773 @default.
- W4310762502 cites W2981385529 @default.
- W4310762502 cites W2996064079 @default.
- W4310762502 cites W2998313718 @default.
- W4310762502 cites W3003139351 @default.
- W4310762502 cites W3008801357 @default.
- W4310762502 cites W3087926226 @default.
- W4310762502 cites W3092041441 @default.
- W4310762502 cites W3106609816 @default.
- W4310762502 cites W3107797873 @default.
- W4310762502 cites W3109114979 @default.
- W4310762502 cites W3111561901 @default.
- W4310762502 cites W3112986493 @default.
- W4310762502 cites W3114195050 @default.
- W4310762502 cites W3116787758 @default.
- W4310762502 cites W3137045793 @default.
- W4310762502 cites W3197082108 @default.
- W4310762502 cites W3207573978 @default.
- W4310762502 cites W3213903348 @default.
- W4310762502 cites W3216749116 @default.
- W4310762502 cites W4210980460 @default.
- W4310762502 cites W4220930820 @default.
- W4310762502 doi "https://doi.org/10.1016/j.jff.2022.105351" @default.
- W4310762502 hasPublicationYear "2022" @default.
- W4310762502 type Work @default.
- W4310762502 citedByCount "1" @default.
- W4310762502 countsByYear W43107625022023 @default.
- W4310762502 crossrefType "journal-article" @default.
- W4310762502 hasAuthorship W4310762502A5016748416 @default.
- W4310762502 hasAuthorship W4310762502A5034694275 @default.
- W4310762502 hasAuthorship W4310762502A5049114928 @default.
- W4310762502 hasAuthorship W4310762502A5059358267 @default.
- W4310762502 hasAuthorship W4310762502A5064218064 @default.
- W4310762502 hasAuthorship W4310762502A5068080767 @default.
- W4310762502 hasAuthorship W4310762502A5070812231 @default.
- W4310762502 hasAuthorship W4310762502A5071530636 @default.
- W4310762502 hasAuthorship W4310762502A5074196854 @default.
- W4310762502 hasAuthorship W4310762502A5080102032 @default.
- W4310762502 hasAuthorship W4310762502A5086932000 @default.
- W4310762502 hasBestOaLocation W43107625021 @default.
- W4310762502 hasConcept C100544194 @default.
- W4310762502 hasConcept C104317684 @default.
- W4310762502 hasConcept C126322002 @default.
- W4310762502 hasConcept C134018914 @default.
- W4310762502 hasConcept C170493617 @default.
- W4310762502 hasConcept C185592680 @default.
- W4310762502 hasConcept C190283241 @default.
- W4310762502 hasConcept C2776070231 @default.
- W4310762502 hasConcept C2776637226 @default.
- W4310762502 hasConcept C2776914184 @default.