FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310772623> ?p ?o ?g. }

• W4310772623 endingPage "e005447" @default.
• W4310772623 startingPage "e005447" @default.
• W4310772623 abstract "Background Despite the survival benefits observed with immune checkpoint blockade (ICB) treatment—programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1), many patients with cancer have not benefited from these agents because of impaired antigen presentation and other resistance mechanisms. To overcome resistance to checkpoint therapy, we designed bispecific antibodies (BsAbs) targeting CD89 and tumor antigens. We demonstrated their immunomodulatory efficacy as a separate treatment strategy or combined with immune checkpoint inhibitors. Methods We have previously generated a heterodimeric one-arm IgG1 Fc-based bispecific antibody. For animal efficacy studies, murine tumors in a humanized transgenic mice model were used to determine the effects of CD89-bispecific antibodies on antigen presentation and immune cell recruitment. The efficacy of the CD89 bispecific antibody against tumors resistant to pembrolizumab was evaluated in double-transgenic mice. Results BsAbs targeting CD89 on tumor-associated macrophages (TAMs) increased the ratio of M1:M2 and activated the antigen presentation, leading to increased cytotoxic T cell-mediated tumor regression. CD89-BsAbs also potentiated a combinational antitumor effect with PD-1/PD-L1 inhibitors and overcame the ICB resistance by augmenting cytotoxic T-cell infiltration and reshaping tumor immune microenvironment. In an hCD89/hPD-1 double transgenic mouse model engrafted with pembrolizumab-resistant B16-HER2 tumor cells, the HER2-CD89 bispecific antibody potently inhibited tumor growth. Conclusions CD89 BsAbs targeting tumor antigens and TAMs controlled tumor growth in animal models by improving antigen presentation and T-cell infiltration. Our results suggest a general strategy for overcoming resistance to ICB." @default.
• W4310772623 created "2022-12-17" @default.
• W4310772623 creator A5023341211 @default.
• W4310772623 creator A5032119620 @default.
• W4310772623 creator A5033471083 @default.
• W4310772623 creator A5040862416 @default.
• W4310772623 creator A5051138947 @default.
• W4310772623 creator A5055667105 @default.
• W4310772623 creator A5057891766 @default.
• W4310772623 creator A5076476786 @default.
• W4310772623 creator A5076486932 @default.
• W4310772623 creator A5084035201 @default.
• W4310772623 creator A5089869726 @default.
• W4310772623 date "2022-12-01" @default.
• W4310772623 modified "2023-10-14" @default.
• W4310772623 title "Targeting CD89 on tumor-associated macrophages overcomes resistance to immune checkpoint blockade" @default.
• W4310772623 cites W1485131138 @default.
• W4310772623 cites W1878923342 @default.
• W4310772623 cites W1971620413 @default.
• W4310772623 cites W1992054873 @default.
• W4310772623 cites W2026878412 @default.
• W4310772623 cites W2026968254 @default.
• W4310772623 cites W2069354590 @default.
• W4310772623 cites W2076743146 @default.
• W4310772623 cites W2097733789 @default.
• W4310772623 cites W2123023182 @default.
• W4310772623 cites W2123105952 @default.
• W4310772623 cites W2133346943 @default.
• W4310772623 cites W2139419109 @default.
• W4310772623 cites W2143239528 @default.
• W4310772623 cites W2143772132 @default.
• W4310772623 cites W2144077203 @default.
• W4310772623 cites W2150678612 @default.
• W4310772623 cites W2154054971 @default.
• W4310772623 cites W2154339682 @default.
• W4310772623 cites W2190773785 @default.
• W4310772623 cites W2292383635 @default.
• W4310772623 cites W2341289486 @default.
• W4310772623 cites W2465860350 @default.
• W4310772623 cites W2501447942 @default.
• W4310772623 cites W2520601585 @default.
• W4310772623 cites W2526282664 @default.
• W4310772623 cites W2587048937 @default.
• W4310772623 cites W2595182131 @default.
• W4310772623 cites W2612649234 @default.
• W4310772623 cites W2615301036 @default.
• W4310772623 cites W2750781282 @default.
• W4310772623 cites W2755073646 @default.
• W4310772623 cites W2755709174 @default.
• W4310772623 cites W2766738495 @default.
• W4310772623 cites W2782007611 @default.
• W4310772623 cites W2782998220 @default.
• W4310772623 cites W2783417222 @default.
• W4310772623 cites W2784732900 @default.
• W4310772623 cites W2785396374 @default.
• W4310772623 cites W2914311347 @default.
• W4310772623 cites W2919865128 @default.
• W4310772623 doi "https://doi.org/10.1136/jitc-2022-005447" @default.
• W4310772623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36460336" @default.
• W4310772623 hasPublicationYear "2022" @default.
• W4310772623 type Work @default.
• W4310772623 citedByCount "1" @default.
• W4310772623 countsByYear W43107726232023 @default.
• W4310772623 crossrefType "journal-article" @default.
• W4310772623 hasAuthorship W4310772623A5023341211 @default.
• W4310772623 hasAuthorship W4310772623A5032119620 @default.
• W4310772623 hasAuthorship W4310772623A5033471083 @default.
• W4310772623 hasAuthorship W4310772623A5040862416 @default.
• W4310772623 hasAuthorship W4310772623A5051138947 @default.
• W4310772623 hasAuthorship W4310772623A5055667105 @default.
• W4310772623 hasAuthorship W4310772623A5057891766 @default.
• W4310772623 hasAuthorship W4310772623A5076476786 @default.
• W4310772623 hasAuthorship W4310772623A5076486932 @default.
• W4310772623 hasAuthorship W4310772623A5084035201 @default.
• W4310772623 hasAuthorship W4310772623A5089869726 @default.
• W4310772623 hasBestOaLocation W43107726231 @default.
• W4310772623 hasConcept C126322002 @default.
• W4310772623 hasConcept C147483822 @default.
• W4310772623 hasConcept C154317977 @default.
• W4310772623 hasConcept C159654299 @default.
• W4310772623 hasConcept C170493617 @default.
• W4310772623 hasConcept C202751555 @default.
• W4310772623 hasConcept C203014093 @default.
• W4310772623 hasConcept C2776090121 @default.
• W4310772623 hasConcept C2776107976 @default.
• W4310772623 hasConcept C2776662205 @default.
• W4310772623 hasConcept C2777701055 @default.
• W4310772623 hasConcept C2778468042 @default.
• W4310772623 hasConcept C2780057760 @default.
• W4310772623 hasConcept C2780851360 @default.
• W4310772623 hasConcept C502942594 @default.
• W4310772623 hasConcept C55493867 @default.
• W4310772623 hasConcept C71924100 @default.
• W4310772623 hasConcept C83464605 @default.
• W4310772623 hasConcept C86803240 @default.
• W4310772623 hasConcept C8891405 @default.
• W4310772623 hasConceptScore W4310772623C126322002 @default.
• W4310772623 hasConceptScore W4310772623C147483822 @default.

• next