Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310773161> ?p ?o ?g. }
- W4310773161 abstract "Chronic kidney disease (CKD) affects kidney cancer patients' mortality. However, the underlying mechanism remains unknown. M2-like macrophages have pro-tumor functions, also exist in injured kidney, and promote kidney fibrosis. Thus, it is suspected that M2-like macrophages in injured kidney induce the pro-tumor microenvironment leading to kidney cancer progression. We found that M2-like macrophages present in the injured kidney promoted kidney cancer progression and induced resistance to anti-PD1 antibody through its pro-tumor function and inhibition of CD8+ T cell infiltration. RNA-seq revealed Slc7a11 was upregulated in M2-like macrophages. Inhibition of Slc7a11 with sulfasalazine inhibited the pro-tumor function of M2-like macrophages and synergized with anti-PD1 antibody. Moreover, SLC7A11-positive macrophages were associated with poor prognosis among kidney cancer patients. Collectively, this study dissects the characteristic microenvironment in the injured kidney that contributed to kidney cancer progression and anti-PD1 antibody resistance. This insight offers promising combination therapy with anti-PD1 antibody and macrophage targeted therapy." @default.
- W4310773161 created "2022-12-17" @default.
- W4310773161 creator A5007057754 @default.
- W4310773161 creator A5007970106 @default.
- W4310773161 creator A5011690214 @default.
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- W4310773161 creator A5016845679 @default.
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- W4310773161 creator A5034239392 @default.
- W4310773161 creator A5036113498 @default.
- W4310773161 creator A5044869736 @default.
- W4310773161 creator A5053519119 @default.
- W4310773161 creator A5064029611 @default.
- W4310773161 creator A5070428340 @default.
- W4310773161 creator A5074043474 @default.
- W4310773161 date "2022-12-05" @default.
- W4310773161 modified "2023-10-14" @default.
- W4310773161 title "Effect of M2-like macrophages of the injured-kidney cortex on kidney cancer progression" @default.
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