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- W4310774923 abstract "Advances in genome sequencing techniques produced a significant growth of phylogenomic datasets. This massive amount of data represents a computational challenge for molecular dating with Bayesian approaches. Rapid molecular dating methods have been proposed over the last few decades to overcome these issues. However, a comparative evaluation of their relative performance on empirical data sets is lacking. We analyzed 23 empirical phylogenomic datasets to investigate the performance of two commonly employed fast dating methodologies: penalized likelihood (PL), implemented in treePL, and the relative rate framework (RRF), implemented in RelTime. They were compared to Bayesian analyses using the closest possible substitution models and calibration settings. We found that RRF was computationally faster and generally provided node age estimates statistically equivalent to Bayesian divergence times. PL time estimates consistently exhibited low levels of uncertainty. Overall, to approximate Bayesian approaches, RelTime is an efficient method with significantly lower computational demand, being more than 100 times faster than treePL. Thus, to alleviate the computational burden of Bayesian divergence time inference in the era of massive genomic data, molecular dating can be facilitated using the RRF, allowing evolutionary hypotheses to be tested more quickly and efficiently." @default.
- W4310774923 created "2022-12-17" @default.
- W4310774923 creator A5004799049 @default.
- W4310774923 creator A5047456701 @default.
- W4310774923 creator A5052758476 @default.
- W4310774923 date "2022-12-03" @default.
- W4310774923 modified "2023-10-06" @default.
- W4310774923 title "Assessing the relative performance of fast molecular dating methods for phylogenomic data" @default.
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- W4310774923 doi "https://doi.org/10.1186/s12864-022-09030-5" @default.