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- W4310776373 abstract "Elevated circulating dipeptidyl peptidase-4 (DPP4) is a biomarker for liver disease, but its involvement in gluconeogenesis and metabolic associated fatty liver disease progression remains unclear. Here, we identified that DPP4 in hepatocytes but not TEK receptor tyrosine kinase–positive endothelial cells regulates the local bioactivity of incretin hormones and gluconeogenesis. However, the complete absence of DPP4 (Dpp4–/–) in aged mice with metabolic syndrome accelerates liver fibrosis without altering dyslipidemia and steatosis. Analysis of transcripts from the livers of Dpp4–/– mice displayed enrichment for inflammasome, p53, and senescence programs compared with littermate controls. High-fat, high-cholesterol feeding decreased Dpp4 expression in F4/80+ cells, with only minor changes in immune signaling. Moreover, in a lean mouse model of severe nonalcoholic fatty liver disease, phosphatidylethanolamine N-methyltransferase mice, we observed a 4-fold increase in circulating DPP4, in contrast with previous findings connecting DPP4 release and obesity. Last, we evaluated DPP4 levels in patients with hepatitis C infection with dysglycemia (Homeostatic Model Assessment of Insulin Resistance > 2) who underwent direct antiviral treatment (with/without ribavirin). DPP4 protein levels decreased with viral clearance; DPP4 activity levels were reduced at long-term follow-up in ribavirin-treated patients; but metabolic factors did not improve. These data suggest elevations in DPP4 during hepatitis C infection are not primarily regulated by metabolic disturbances." @default.
- W4310776373 created "2022-12-17" @default.
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- W4310776373 date "2023-01-24" @default.
- W4310776373 modified "2023-09-26" @default.
- W4310776373 title "Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, modulates glucose production, and when absent influences NAFLD progression" @default.
- W4310776373 cites W1570779967 @default.
- W4310776373 cites W1617495083 @default.
- W4310776373 cites W1891161709 @default.
- W4310776373 cites W1969322346 @default.
- W4310776373 cites W1970498822 @default.
- W4310776373 cites W1974863952 @default.
- W4310776373 cites W1979916078 @default.
- W4310776373 cites W1981985904 @default.
- W4310776373 cites W1985236262 @default.
- W4310776373 cites W1990714106 @default.
- W4310776373 cites W2003537536 @default.
- W4310776373 cites W2004701807 @default.
- W4310776373 cites W2009668465 @default.
- W4310776373 cites W2013907285 @default.
- W4310776373 cites W2015519364 @default.
- W4310776373 cites W2035452635 @default.
- W4310776373 cites W2036518174 @default.
- W4310776373 cites W2037918682 @default.
- W4310776373 cites W2054564814 @default.
- W4310776373 cites W2055183906 @default.
- W4310776373 cites W2057820609 @default.
- W4310776373 cites W2060252363 @default.
- W4310776373 cites W2066714304 @default.
- W4310776373 cites W2093276420 @default.
- W4310776373 cites W2098509177 @default.
- W4310776373 cites W2108589716 @default.
- W4310776373 cites W2109288527 @default.
- W4310776373 cites W2110317359 @default.
- W4310776373 cites W2116898765 @default.
- W4310776373 cites W2121497054 @default.
- W4310776373 cites W2131821161 @default.
- W4310776373 cites W2136547076 @default.
- W4310776373 cites W2138197806 @default.
- W4310776373 cites W2152557643 @default.
- W4310776373 cites W2152731692 @default.
- W4310776373 cites W2157689573 @default.
- W4310776373 cites W2168526937 @default.
- W4310776373 cites W2210672989 @default.
- W4310776373 cites W2223377380 @default.
- W4310776373 cites W2417150610 @default.
- W4310776373 cites W2531363533 @default.
- W4310776373 cites W2552031787 @default.
- W4310776373 cites W2556857110 @default.
- W4310776373 cites W2562949639 @default.
- W4310776373 cites W2593571692 @default.
- W4310776373 cites W2595853302 @default.
- W4310776373 cites W2741958922 @default.
- W4310776373 cites W2743822989 @default.
- W4310776373 cites W2745520112 @default.
- W4310776373 cites W2752614382 @default.
- W4310776373 cites W2772170000 @default.
- W4310776373 cites W2781705452 @default.
- W4310776373 cites W2783035435 @default.
- W4310776373 cites W2789232986 @default.
- W4310776373 cites W2789332567 @default.
- W4310776373 cites W2795481136 @default.
- W4310776373 cites W2811001233 @default.
- W4310776373 cites W2886865853 @default.
- W4310776373 cites W2898846041 @default.
- W4310776373 cites W2899339394 @default.
- W4310776373 cites W2902538813 @default.
- W4310776373 cites W2909281962 @default.
- W4310776373 cites W2912209115 @default.
- W4310776373 cites W2912918280 @default.
- W4310776373 cites W2914141586 @default.
- W4310776373 cites W2922015353 @default.
- W4310776373 cites W2940492200 @default.
- W4310776373 cites W2950304894 @default.
- W4310776373 cites W2956021019 @default.
- W4310776373 cites W2960962641 @default.
- W4310776373 cites W2972217240 @default.
- W4310776373 cites W2990611169 @default.