FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310778315> ?p ?o ?g. }

• W4310778315 endingPage "101152" @default.
• W4310778315 startingPage "101152" @default.
• W4310778315 abstract "The lens is an important determinant of overall vision quality whose refractive and transparent properties change throughout life. Alterations to the refractive properties of the lens contribute to the process of emmetropisation in early childhood, and then the gradual loss in lens power that occurs throughout adulthood. In parallel to these changes to lens refractive power, age-dependent increases in lens stiffness and light scattering result in presbyopia and cataract, respectively. In recent years it has been confirmed that the lens operates an internal microcirculation system that generates circulating fluxes of ions, water and nutrients that maintain the refractive properties and transparency of the lens. By actively regulating lens water content, the microcirculation system controls two key parameters, lens geometry and the gradient of refractive index, which together determine the refractive properties of the lens. Furthermore, by delivering nutrients and antioxidants to the lens nucleus, the microcirculation system maintains lens transparency by preventing crystallin aggregation. Interestingly, the solubility, intramolecular packing and refractive index increment of crystallin proteins can be modulated by the ability of crystallin proteins to dynamically bind water, a processed called syneresis. In a series of previous studies it has been shown that the application of external pressure to the lens can induce syneresis. Since it is now known that lens water transport generates a substantial internal hydrostatic pressure gradient, we speculate that the microcirculation is capable of regulating crystallin function by altering the amount of water bound to lens proteins in the nucleus, where the pressure gradient and protein concentrations are the highest. Here we present evidence for the links between lens transport, pressure, syneresis and protein function. Furthermore, because the lens pressure gradient can be regulated by intrinsic and extrinsic stimuli, we suggest mechanisms via which this integrative system can be used to effect the changes to the refractive and transparent properties of the lens that are observed across our lifetime." @default.
• W4310778315 created "2022-12-17" @default.
• W4310778315 creator A5003905457 @default.
• W4310778315 creator A5037124694 @default.
• W4310778315 creator A5049292595 @default.
• W4310778315 creator A5075009221 @default.
• W4310778315 creator A5078076335 @default.
• W4310778315 date "2023-07-01" @default.
• W4310778315 modified "2023-10-17" @default.
• W4310778315 title "Regulation of lens water content: Effects on the physiological optics of the lens" @default.
• W4310778315 cites W1536119583 @default.
• W4310778315 cites W1543060992 @default.
• W4310778315 cites W1543360531 @default.
• W4310778315 cites W1601916871 @default.
• W4310778315 cites W1634882007 @default.
• W4310778315 cites W1920443043 @default.
• W4310778315 cites W1944111067 @default.
• W4310778315 cites W1944557939 @default.
• W4310778315 cites W1959628050 @default.
• W4310778315 cites W1965107460 @default.
• W4310778315 cites W1966720374 @default.
• W4310778315 cites W1967429157 @default.
• W4310778315 cites W1970589352 @default.
• W4310778315 cites W1973312356 @default.
• W4310778315 cites W1974308660 @default.
• W4310778315 cites W1975751336 @default.
• W4310778315 cites W1977341549 @default.
• W4310778315 cites W1977809782 @default.
• W4310778315 cites W1978067462 @default.
• W4310778315 cites W1982287114 @default.
• W4310778315 cites W1983178795 @default.
• W4310778315 cites W1983819959 @default.
• W4310778315 cites W1984020616 @default.
• W4310778315 cites W1985042934 @default.
• W4310778315 cites W1986497914 @default.
• W4310778315 cites W1990076368 @default.
• W4310778315 cites W1990225146 @default.
• W4310778315 cites W1992341964 @default.
• W4310778315 cites W1993197220 @default.
• W4310778315 cites W1995994950 @default.
• W4310778315 cites W1997852369 @default.
• W4310778315 cites W1997963479 @default.
• W4310778315 cites W1998925732 @default.
• W4310778315 cites W2001103943 @default.
• W4310778315 cites W2004335298 @default.
• W4310778315 cites W2009983456 @default.
• W4310778315 cites W2011779030 @default.
• W4310778315 cites W2012697282 @default.
• W4310778315 cites W2013380076 @default.
• W4310778315 cites W2014138347 @default.
• W4310778315 cites W2014679165 @default.
• W4310778315 cites W2015339197 @default.
• W4310778315 cites W2016883866 @default.
• W4310778315 cites W2017589495 @default.
• W4310778315 cites W2021786044 @default.
• W4310778315 cites W2026280683 @default.
• W4310778315 cites W2026368547 @default.
• W4310778315 cites W2030946728 @default.
• W4310778315 cites W2031908838 @default.
• W4310778315 cites W2032652519 @default.
• W4310778315 cites W2033886854 @default.
• W4310778315 cites W2034085028 @default.
• W4310778315 cites W2034199372 @default.
• W4310778315 cites W2036682047 @default.
• W4310778315 cites W2037023131 @default.
• W4310778315 cites W2037270631 @default.
• W4310778315 cites W2040353669 @default.
• W4310778315 cites W2040664792 @default.
• W4310778315 cites W2041146980 @default.
• W4310778315 cites W2044031095 @default.
• W4310778315 cites W2045170222 @default.
• W4310778315 cites W2047651912 @default.
• W4310778315 cites W2047959280 @default.
• W4310778315 cites W2048641604 @default.
• W4310778315 cites W2050614422 @default.
• W4310778315 cites W2051060938 @default.
• W4310778315 cites W2053810563 @default.
• W4310778315 cites W2055218251 @default.
• W4310778315 cites W2055538694 @default.
• W4310778315 cites W2057592454 @default.
• W4310778315 cites W2059470236 @default.
• W4310778315 cites W2066022764 @default.
• W4310778315 cites W2066207306 @default.
• W4310778315 cites W2066303560 @default.
• W4310778315 cites W2068010422 @default.
• W4310778315 cites W2068431592 @default.
• W4310778315 cites W2068882937 @default.
• W4310778315 cites W2070080908 @default.
• W4310778315 cites W2070336920 @default.
• W4310778315 cites W2070762010 @default.
• W4310778315 cites W2072082167 @default.
• W4310778315 cites W2072722945 @default.
• W4310778315 cites W2072982588 @default.
• W4310778315 cites W2074006918 @default.
• W4310778315 cites W2074947501 @default.
• W4310778315 cites W2075194901 @default.
• W4310778315 cites W2077048490 @default.
• W4310778315 cites W2078231330 @default.

• next