Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310778643> ?p ?o ?g. }
- W4310778643 abstract "In situ vaccination is a promising strategy to convert the immunosuppressive tumor microenvironment into an immunostimulatory one with limited systemic exposure and side effect. However, sustained clinical benefits require long-term and multidimensional immune activation including innate and adaptive immunity. Here, we develop a probiotic food-grade Lactococcus lactis-based in situ vaccination (FOLactis) expressing a fusion protein of Fms-like tyrosine kinase 3 ligand and co-stimulator OX40 ligand. Intratumoural delivery of FOLactis contributes to local retention and sustained release of therapeutics to thoroughly modulate key components of the antitumour immune response, such as activation of natural killer cells, cytotoxic T lymphocytes, and conventional-type-1-dendritic cells in the tumors and tumor-draining lymph nodes. In addition, intratumoural administration of FOLactis induces a more robust tumor antigen-specific immune response and superior systemic antitumour efficacy in multiple poorly immune cell-infiltrated and anti-PD1-resistant tumors. Specific depletion of different immune cells reveals that CD8+ T and natural killer cells are crucial to the in situ vaccine-elicited tumor regression. Our results confirm that FOLactis displays an enhanced antitumour immunity and successfully converts the 'cold' tumors to 'hot' tumors." @default.
- W4310778643 created "2022-12-17" @default.
- W4310778643 creator A5001277532 @default.
- W4310778643 creator A5001281921 @default.
- W4310778643 creator A5013653434 @default.
- W4310778643 creator A5030065149 @default.
- W4310778643 creator A5044308307 @default.
- W4310778643 creator A5045723123 @default.
- W4310778643 creator A5049630854 @default.
- W4310778643 creator A5051938451 @default.
- W4310778643 creator A5052458023 @default.
- W4310778643 creator A5053447486 @default.
- W4310778643 creator A5053609156 @default.
- W4310778643 creator A5071375088 @default.
- W4310778643 creator A5085558954 @default.
- W4310778643 creator A5090210582 @default.
- W4310778643 date "2022-12-03" @default.
- W4310778643 modified "2023-10-15" @default.
- W4310778643 title "Engineered Lactococcus lactis secreting Flt3L and OX40 ligand for in situ vaccination-based cancer immunotherapy" @default.
- W4310778643 cites W1498931318 @default.
- W4310778643 cites W1962890795 @default.
- W4310778643 cites W1966338031 @default.
- W4310778643 cites W1989623935 @default.
- W4310778643 cites W2006345064 @default.
- W4310778643 cites W2029128444 @default.
- W4310778643 cites W2052550272 @default.
- W4310778643 cites W2071875829 @default.
- W4310778643 cites W2081287274 @default.
- W4310778643 cites W2081654862 @default.
- W4310778643 cites W2083089709 @default.
- W4310778643 cites W2091587044 @default.
- W4310778643 cites W2092235636 @default.
- W4310778643 cites W2111516447 @default.
- W4310778643 cites W2123118110 @default.
- W4310778643 cites W2134403422 @default.
- W4310778643 cites W2189381691 @default.
- W4310778643 cites W2276458148 @default.
- W4310778643 cites W2298512893 @default.
- W4310778643 cites W2323086376 @default.
- W4310778643 cites W2461271870 @default.
- W4310778643 cites W2466689966 @default.
- W4310778643 cites W2561279433 @default.
- W4310778643 cites W2561499686 @default.
- W4310778643 cites W2576658154 @default.
- W4310778643 cites W2596760231 @default.
- W4310778643 cites W2617871758 @default.
- W4310778643 cites W2619290461 @default.
- W4310778643 cites W2765314233 @default.
- W4310778643 cites W2782333299 @default.
- W4310778643 cites W2786472249 @default.
- W4310778643 cites W2787835497 @default.
- W4310778643 cites W2791931250 @default.
- W4310778643 cites W2799553179 @default.
- W4310778643 cites W2885926750 @default.
- W4310778643 cites W2899862051 @default.
- W4310778643 cites W2938889495 @default.
- W4310778643 cites W2996716598 @default.
- W4310778643 cites W3005566802 @default.
- W4310778643 cites W3005633099 @default.
- W4310778643 cites W3023043704 @default.
- W4310778643 cites W3024276903 @default.
- W4310778643 cites W3046780653 @default.
- W4310778643 cites W3049052172 @default.
- W4310778643 cites W3080941761 @default.
- W4310778643 cites W3093225819 @default.
- W4310778643 cites W3097463205 @default.
- W4310778643 cites W3111998143 @default.
- W4310778643 cites W3139465266 @default.
- W4310778643 cites W3160126603 @default.
- W4310778643 cites W3181724709 @default.
- W4310778643 cites W3199385148 @default.
- W4310778643 cites W3200145496 @default.
- W4310778643 cites W343688389 @default.
- W4310778643 cites W4205511360 @default.
- W4310778643 cites W4206420692 @default.
- W4310778643 cites W4220768365 @default.
- W4310778643 doi "https://doi.org/10.1038/s41467-022-35130-7" @default.
- W4310778643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36463242" @default.
- W4310778643 hasPublicationYear "2022" @default.
- W4310778643 type Work @default.
- W4310778643 citedByCount "3" @default.
- W4310778643 countsByYear W43107786432023 @default.
- W4310778643 crossrefType "journal-article" @default.
- W4310778643 hasAuthorship W4310778643A5001277532 @default.
- W4310778643 hasAuthorship W4310778643A5001281921 @default.
- W4310778643 hasAuthorship W4310778643A5013653434 @default.
- W4310778643 hasAuthorship W4310778643A5030065149 @default.
- W4310778643 hasAuthorship W4310778643A5044308307 @default.
- W4310778643 hasAuthorship W4310778643A5045723123 @default.
- W4310778643 hasAuthorship W4310778643A5049630854 @default.
- W4310778643 hasAuthorship W4310778643A5051938451 @default.
- W4310778643 hasAuthorship W4310778643A5052458023 @default.
- W4310778643 hasAuthorship W4310778643A5053447486 @default.
- W4310778643 hasAuthorship W4310778643A5053609156 @default.
- W4310778643 hasAuthorship W4310778643A5071375088 @default.
- W4310778643 hasAuthorship W4310778643A5085558954 @default.
- W4310778643 hasAuthorship W4310778643A5090210582 @default.
- W4310778643 hasBestOaLocation W43107786431 @default.
- W4310778643 hasConcept C154317977 @default.
- W4310778643 hasConcept C167672396 @default.