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- W4310778797 abstract "Viruses are masters at using cellular pathways to aid their replication. Cryo-electron tomography of poliovirus-infected cells revealed how it utilizes macroautophagy to its advantage. Assembly of these non-enveloped virions takes place directly on membranes and requires PIK3C3/VPS34 activity to be completed, whereas the canonical autophagy inducer ULK1 restricts virus assembly. The tomograms further revealed that enterovirus-induced autophagy is selective for RNA-loaded virions, which may help ensure maximum infectivity of the virus-laden vesicles released through secretory autophagy." @default.
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- W4310778797 date "2022-12-05" @default.
- W4310778797 modified "2023-10-04" @default.
- W4310778797 title "A 3D view of how enteroviruses hijack autophagy" @default.
- W4310778797 cites W4304098669 @default.
- W4310778797 doi "https://doi.org/10.1080/15548627.2022.2153572" @default.
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