Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310778801> ?p ?o ?g. }
- W4310778801 abstract "Improving muscle function has great potential to improve the quality of life. To identify novel regulators of skeletal muscle metabolism and function, we performed a proteomic analysis of gastrocnemius muscle from 73 genetically distinct inbred mouse strains, and integrated the data with previously acquired genomics and >300 molecular/phenotypic traits via quantitative trait loci mapping and correlation network analysis. These data identified thousands of associations between protein abundance and phenotypes and can be accessed online ( https://muscle.coffeeprot.com/ ) to identify regulators of muscle function. We used this resource to prioritize targets for a functional genomic screen in human bioengineered skeletal muscle. This identified several negative regulators of muscle function including UFC1, an E2 ligase for protein UFMylation. We show UFMylation is up-regulated in a mouse model of amyotrophic lateral sclerosis, a disease that involves muscle atrophy. Furthermore, in vivo knockdown of UFMylation increased contraction force, implicating its role as a negative regulator of skeletal muscle function." @default.
- W4310778801 created "2022-12-17" @default.
- W4310778801 creator A5006865443 @default.
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- W4310778801 date "2022-12-06" @default.
- W4310778801 modified "2023-10-14" @default.
- W4310778801 title "Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function" @default.
- W4310778801 cites W1563940013 @default.
- W4310778801 cites W1966327575 @default.
- W4310778801 cites W1969839871 @default.
- W4310778801 cites W1971643509 @default.
- W4310778801 cites W1979441857 @default.
- W4310778801 cites W1985238823 @default.
- W4310778801 cites W1991203132 @default.
- W4310778801 cites W1992994645 @default.
- W4310778801 cites W2000653200 @default.
- W4310778801 cites W2007056893 @default.
- W4310778801 cites W2016745966 @default.
- W4310778801 cites W2018145766 @default.
- W4310778801 cites W2022367303 @default.
- W4310778801 cites W2024405748 @default.
- W4310778801 cites W2026465178 @default.
- W4310778801 cites W2032053493 @default.
- W4310778801 cites W2033295792 @default.
- W4310778801 cites W2041399392 @default.
- W4310778801 cites W2045397466 @default.
- W4310778801 cites W2053674619 @default.
- W4310778801 cites W2053943711 @default.
- W4310778801 cites W2058537776 @default.
- W4310778801 cites W2062859898 @default.
- W4310778801 cites W2065070435 @default.
- W4310778801 cites W2065096062 @default.
- W4310778801 cites W2066961060 @default.
- W4310778801 cites W2087023216 @default.
- W4310778801 cites W2089335658 @default.
- W4310778801 cites W2089372097 @default.
- W4310778801 cites W2099540110 @default.
- W4310778801 cites W2106226122 @default.
- W4310778801 cites W2107940314 @default.
- W4310778801 cites W2125662116 @default.
- W4310778801 cites W2126066248 @default.
- W4310778801 cites W2127684760 @default.
- W4310778801 cites W2135427146 @default.
- W4310778801 cites W2143451832 @default.
- W4310778801 cites W2146512944 @default.
- W4310778801 cites W2150904206 @default.
- W4310778801 cites W2164314951 @default.
- W4310778801 cites W2164824419 @default.
- W4310778801 cites W2164995845 @default.
- W4310778801 cites W2165700891 @default.
- W4310778801 cites W2206804682 @default.
- W4310778801 cites W2302275992 @default.
- W4310778801 cites W2330052944 @default.
- W4310778801 cites W2341820027 @default.
- W4310778801 cites W2342116893 @default.
- W4310778801 cites W2411397641 @default.
- W4310778801 cites W2415103133 @default.
- W4310778801 cites W2417483443 @default.
- W4310778801 cites W2434017435 @default.
- W4310778801 cites W2512812535 @default.
- W4310778801 cites W2546932883 @default.
- W4310778801 cites W2550900176 @default.
- W4310778801 cites W2566116513 @default.
- W4310778801 cites W2582807684 @default.
- W4310778801 cites W2588139401 @default.
- W4310778801 cites W2593037083 @default.
- W4310778801 cites W2604951703 @default.
- W4310778801 cites W2605868587 @default.
- W4310778801 cites W2754548624 @default.
- W4310778801 cites W2768737006 @default.
- W4310778801 cites W2778030995 @default.
- W4310778801 cites W2791407945 @default.
- W4310778801 cites W2801491392 @default.
- W4310778801 cites W2805712258 @default.
- W4310778801 cites W2808070351 @default.
- W4310778801 cites W2808430950 @default.
- W4310778801 cites W2810092780 @default.
- W4310778801 cites W2885870007 @default.
- W4310778801 cites W2899630292 @default.
- W4310778801 cites W2899760200 @default.
- W4310778801 cites W2903458287 @default.
- W4310778801 cites W2909869524 @default.
- W4310778801 cites W2910861117 @default.
- W4310778801 cites W2917430324 @default.
- W4310778801 cites W2920817727 @default.