FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310781333> ?p ?o ?g. }

• W4310781333 endingPage "587" @default.
• W4310781333 startingPage "579" @default.
• W4310781333 abstract "Abstract Psychosis in disorders like schizophrenia is commonly associated with aberrant salience and elevated striatal dopamine. However, the underlying cause(s) of this hyper-dopaminergic state remain elusive. Various lines of evidence point to glutamatergic dysfunction and impairments in synaptic plasticity in the etiology of schizophrenia, including deficits associated with the GluA1 AMPAR subunit. GluA1 knockout ( Gria1 −/− ) mice provide a model of impaired synaptic plasticity in schizophrenia and exhibit a selective deficit in a form of short-term memory which underlies short-term habituation. As such, these mice are unable to reduce attention to recently presented stimuli. In this study we used fast-scan cyclic voltammetry to measure phasic dopamine responses in the nucleus accumbens of Gria1 −/− mice to determine whether this behavioral phenotype might be a key driver of a hyper-dopaminergic state. There was no effect of GluA1 deletion on electrically-evoked dopamine responses in anaesthetized mice, demonstrating normal endogenous release properties of dopamine neurons in Gria1 −/− mice. Furthermore, dopamine signals were initially similar in Gria1 −/− mice compared to controls in response to both sucrose rewards and neutral light stimuli. They were also equally sensitive to changes in the magnitude of delivered rewards. In contrast, however, these stimulus-evoked dopamine signals failed to habituate with repeated presentations in Gria1 −/− mice, resulting in a task-relevant, hyper-dopaminergic phenotype. Thus, here we show that GluA1 dysfunction, resulting in impaired short-term habituation, is a key driver of enhanced striatal dopamine responses, which may be an important contributor to aberrant salience and psychosis in psychiatric disorders like schizophrenia." @default.
• W4310781333 created "2022-12-17" @default.
• W4310781333 creator A5005426383 @default.
• W4310781333 creator A5009783365 @default.
• W4310781333 creator A5024687319 @default.
• W4310781333 creator A5030994595 @default.
• W4310781333 creator A5034002799 @default.
• W4310781333 creator A5041981916 @default.
• W4310781333 creator A5048961414 @default.
• W4310781333 creator A5050681797 @default.
• W4310781333 creator A5058998834 @default.
• W4310781333 creator A5077973342 @default.
• W4310781333 date "2022-12-02" @default.
• W4310781333 modified "2023-10-17" @default.
• W4310781333 title "Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience" @default.
• W4310781333 cites W1544768903 @default.
• W4310781333 cites W1652173018 @default.
• W4310781333 cites W1810663112 @default.
• W4310781333 cites W1814485581 @default.
• W4310781333 cites W1884361550 @default.
• W4310781333 cites W1963772961 @default.
• W4310781333 cites W1978417991 @default.
• W4310781333 cites W1981789373 @default.
• W4310781333 cites W1981983302 @default.
• W4310781333 cites W1985029200 @default.
• W4310781333 cites W1987555292 @default.
• W4310781333 cites W1990964050 @default.
• W4310781333 cites W1992232671 @default.
• W4310781333 cites W1992902151 @default.
• W4310781333 cites W1993683682 @default.
• W4310781333 cites W1994483275 @default.
• W4310781333 cites W1994984635 @default.
• W4310781333 cites W2001514114 @default.
• W4310781333 cites W2008177747 @default.
• W4310781333 cites W2011345925 @default.
• W4310781333 cites W2013514700 @default.
• W4310781333 cites W2026576642 @default.
• W4310781333 cites W2028669852 @default.
• W4310781333 cites W2031889110 @default.
• W4310781333 cites W2034568201 @default.
• W4310781333 cites W2035843419 @default.
• W4310781333 cites W2036494479 @default.
• W4310781333 cites W2036803444 @default.
• W4310781333 cites W2038207214 @default.
• W4310781333 cites W2039547082 @default.
• W4310781333 cites W2043555654 @default.
• W4310781333 cites W2045716255 @default.
• W4310781333 cites W2051629407 @default.
• W4310781333 cites W2058387509 @default.
• W4310781333 cites W2058788536 @default.
• W4310781333 cites W2059763388 @default.
• W4310781333 cites W2061945050 @default.
• W4310781333 cites W2065428337 @default.
• W4310781333 cites W2068276234 @default.
• W4310781333 cites W2068646756 @default.
• W4310781333 cites W2071090720 @default.
• W4310781333 cites W2077656801 @default.
• W4310781333 cites W2079142947 @default.
• W4310781333 cites W2084453479 @default.
• W4310781333 cites W2085866447 @default.
• W4310781333 cites W2088315022 @default.
• W4310781333 cites W2101357408 @default.
• W4310781333 cites W2115095583 @default.
• W4310781333 cites W2115807273 @default.
• W4310781333 cites W2116658855 @default.
• W4310781333 cites W2119268695 @default.
• W4310781333 cites W2121007598 @default.
• W4310781333 cites W2123746482 @default.
• W4310781333 cites W2124284324 @default.
• W4310781333 cites W2124300506 @default.
• W4310781333 cites W2130784302 @default.
• W4310781333 cites W2135442704 @default.
• W4310781333 cites W2143963089 @default.
• W4310781333 cites W2145602532 @default.
• W4310781333 cites W2152681028 @default.
• W4310781333 cites W2160695817 @default.
• W4310781333 cites W2162958801 @default.
• W4310781333 cites W2163773342 @default.
• W4310781333 cites W2168187353 @default.
• W4310781333 cites W2191449095 @default.
• W4310781333 cites W2206955164 @default.
• W4310781333 cites W2271599771 @default.
• W4310781333 cites W2292881981 @default.
• W4310781333 cites W2414596101 @default.
• W4310781333 cites W2414720026 @default.
• W4310781333 cites W2502521380 @default.
• W4310781333 cites W2571008383 @default.
• W4310781333 cites W2587655282 @default.
• W4310781333 cites W2604220916 @default.
• W4310781333 cites W2604246133 @default.
• W4310781333 cites W2754726085 @default.
• W4310781333 cites W2762155578 @default.
• W4310781333 cites W2777013718 @default.
• W4310781333 cites W2884917081 @default.
• W4310781333 cites W2892330318 @default.
• W4310781333 cites W2892806597 @default.
• W4310781333 cites W2897664150 @default.
• W4310781333 cites W2899502175 @default.

• next